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ORIGINAL RESEARCH article

Front. Transplant.
Sec. Abdominal Transplantation
Volume 4 - 2025 | doi: 10.3389/frtra.2025.1534875

Exploring the Role of Metabolomics in Kidney Transplantation: A Systematic Review of the Literature

Provisionally accepted
Cezar Valeriu Băluță Cezar Valeriu Băluță 1Luminița Voroneanu Luminița Voroneanu 1,2Ionut Nistor Ionut Nistor 1,2Lucian Siriteanu Lucian Siriteanu 1,2*Andreea Simona Covic Andreea Simona Covic 1,2Erika Iremie-Băluță Erika Iremie-Băluță 3Mehmet Kanbay Mehmet Kanbay 4Adrian Covic Adrian Covic 1,2Adelina Vasilica Miron Adelina Vasilica Miron 1,2
  • 1 Spitalul Clinic Dr. C. I. Parhon, Iași, Romania
  • 2 Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania
  • 3 Sfanta Parascheva Clinical Hospital for Infectious Diseases, Iasi, Romania
  • 4 Division of Nephrology, Department of Medicine, School of Medicine, Koc University, Istanbul, Türkiye

The final, formatted version of the article will be published soon.

    Background: Serum creatinine and proteinuria remain the most frequently used test for monitoring allograft function. However, they are non-specific and insensitive markers.Metabolomics is an emerging field, dealing with the high-throughput identification and quantification of small molecules metabolites. We aimed to systematically review all available data regarding kidney transplantation and metabolomics.Methods: This is a systematic review evaluating metabolomic usage in kidney transplant patients.A comprehensive search was assembled in the time span extending from inception until March 2024 across MEDLINE (PubMed), Embase and Cochrane. In addition to the databases above, eligible citation were sought through the screening of ClinicalTrials.gov and Google Scholar. Two authors assessed potential citations for eligibility and quality and extracted all data.Results: A total of 57 articles were identified for inclusion (totaling 3821 patients), containing different methodologies and outcomes related to metabolic profiling. We aimed to offer support for finding new biomarkers that could aid in the evaluation of the kidney transplant patient, covering pathophysiological mechanisms and exploring avenues for personalized care.Conclussion: Our systematic review underlines the possible role of metabolomics in monitoring kidney transplant patients. By integrating data from numerous studies, we have detected possible new biomarkers that might transform the method we screen kidney transplant recipients.

    Keywords: kidney transplanation, Systematic review, Metabolomics, Allograft function, kidney reject, Metabolites

    Received: 26 Nov 2024; Accepted: 24 Jan 2025.

    Copyright: © 2025 Băluță, Voroneanu, Nistor, Siriteanu, Covic, Iremie-Băluță, Kanbay, Covic and Miron. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lucian Siriteanu, Spitalul Clinic Dr. C. I. Parhon, Iași, Romania

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.