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CASE REPORT article

Front. Transplant.
Sec. Abdominal Transplantation
Volume 3 - 2024 | doi: 10.3389/frtra.2024.1496702

Management of recurrent UTI with tigecycline in a Kidney transplant recipient: a case report

Provisionally accepted
Supreeta R Shettar Supreeta R Shettar 1Mahadevaiah Neelambike Sumana Mahadevaiah Neelambike Sumana 1*Manjunath S Shetty Manjunath S Shetty 2Yogeesh Maheshwarappa Yogeesh Maheshwarappa 3Raghukanth Reddy Raghukanth Reddy 2Asha Srinivasan Asha Srinivasan 4Vamshi Dharan P Vamshi Dharan P 2Gautam Kalyatanda Gautam Kalyatanda 5Shruthi Shree S C Shruthi Shree S C 1Keerthana V Keerthana V 1
  • 1 Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
  • 2 Department of Nephrology, JSS Medical College and Hospital, JSS AHER, Mysuru, India
  • 3 JSS Medical College & Hospital, JSS Academy of Higher Education and Research, Mysore, India
  • 4 Division of Nanoscience and Technology, School of Life Sciences, JSS AHER, Mysuru, India
  • 5 Division of Infectious Diseases & Global Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, United States

The final, formatted version of the article will be published soon.

    This case report describes a 37-year-old male who underwent renal transplantation and subsequently developed complicated recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae. Despite initial treatment with fosfomycin and meropenem, the patient experienced persistent UTIs, leading to multiple hospitalizations. The management of these recurrent infections eventually required the use of tigecycline. Although tigecycline is not typically considered a urinary antibiotic due to its limited urinary excretion, it was successfully employed in this case to manage the recurrent infections. The patient was treated with tigecycline for several episodes of UTI, which provided a crucial therapeutic option in the context of antibiotic resistance. This case underscores the challenges of managing recurrent MDR UTIs in immunocompromised patients and highlights tigecycline as an effective treatment strategy when standard therapies fail.

    Keywords: multi-drug resistant Klebsiella pneumoniae, Multidrug-resistant organisms, Urinary tract infection, Kidney Transplantation, immunocompromised conditions

    Received: 15 Sep 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Shettar, Sumana, Shetty, Maheshwarappa, Reddy, Srinivasan, P, Kalyatanda, S C and V. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mahadevaiah Neelambike Sumana, Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India

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