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CASE REPORT article

Front. Transplant.
Sec. Abdominal Transplantation
Volume 3 - 2024 | doi: 10.3389/frtra.2024.1494016

Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient

Provisionally accepted
Supreeta R Shettar Supreeta R Shettar 1Mahadevaiah Neelambike Sumana Mahadevaiah Neelambike Sumana 1*Manjunath S Shetty Manjunath S Shetty 2Yogeesh D Maheshwarappa Yogeesh D Maheshwarappa 1Raghukanth Reddy Raghukanth Reddy 2Asha Srinivasan Asha Srinivasan 3Vamshi Dharan P Vamshi Dharan P 2Gautam Kalyatanda Gautam Kalyatanda 4Veerabhadra Swamy G S Veerabhadra Swamy G S 1Chinchana E S Chinchana E S 1
  • 1 Department of Microbiology, JSS Medical College & Hospital, JSS Academy of Higher Education and Research, Mysore, India
  • 2 Dept of Nephrology, JSS Medical College and Hospital, JSS AHER,, Mysuru, India
  • 3 Division of Nanoscience and Technology, School of Life Sciences, JSS AHER, Mysuru, India
  • 4 Division of Infectious Diseases & Global Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, United States

The final, formatted version of the article will be published soon.

    This case report on recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae in a post-renal transplant patient underscores the significant clinical challenge of managing MDR infections in immunocompromised individuals, particularly in the context of renal transplantation. The patient was treated with an extended infusion of meropenem, which offers prolonged drug exposure and enhances bactericidal activity against MDR pathogens. This approach is critical in overcoming the resistance mechanisms inherent to Klebsiella pneumoniae, thereby improving the likelihood of therapeutic success. The findings presented here highlight the potential efficacy of extended meropenem infusion in treating MDR infections, providing a valuable therapeutic option for clinicians facing similar cases. This report contributes to the growing evidence supporting advanced antibiotic administration techniques in managing complicated urinary tract infections in transplant recipients.

    Keywords: Multidrug-resistant organisms, multi-drug resistant Klebsiella pneumoniae, Urinary tract infection, Kidney Transplantation, immunocompromised condition

    Received: 10 Sep 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Shettar, Sumana, Shetty, Maheshwarappa, Reddy, Srinivasan, P, Kalyatanda, S and S. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mahadevaiah Neelambike Sumana, Department of Microbiology, JSS Medical College & Hospital, JSS Academy of Higher Education and Research, Mysore, India

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