AUTHOR=Chui Benedict , Day Richard , Umashankar Eshwar , Abdel Shaheed Christina , Keogh Anne , Girgis Laila , Penglase Ross 

TITLE=Meta-analysis and systematic review of gout prevalence in the heart/lung transplantation population

JOURNAL=Frontiers in Transplantation

VOLUME=3

YEAR=2024

URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2024.1356058

DOI=10.3389/frtra.2024.1356058

ISSN=2813-2440

ABSTRACT=<sec><title>Introduction</title><p>Gout may complicate solid organ transplantation with potentially serious consequences. An accurate prevalence of gout in this population is unknown.</p></sec><sec><title>Objectives</title><p>This study aimed to estimate the prevalence of gout in the heart and/or lung transplantation population through a systematic review and meta-analysis.</p></sec><sec><title>Methods</title><p>MEDLINE, Embase, PsycINFO, CENTRAL and Cochrane Library (inception to February 2022) were searched for studies that reported the prevalence and/or incidence of gout in heart and/or lung transplant recipients. Two authors extracted outcomes data. Data were pooled using a random effects model. Overall quality of evidence was assessed using GRADE. Primary outcomes were the prevalence of pre- or post-transplant gout expressed as a prevalence rate (95% CI). Secondary outcomes included risk factors for gout, adverse events, and therapeutic complications of gout treatment.</p></sec><sec><title>Results</title><p>Ten studies were included. Gout prevalence (PR) was 8% pre-transplant (PR = 0.08; 95% CI: 0.05–0.12; 4 studies <italic>n</italic> = 651) and 6% post-transplant (PR = 0.06; 95% CI: 0.06–0.06; 10 studies <italic>n</italic> = 45,298). Post-transplant gout prevalence in heart transplant recipients was almost three times higher than lung transplant recipients (PR = 0.16; 95% CI: 0.13–0.20 vs. PR = 0.06; 95% CI: 0.05–0.06 respectively). Patients with a pre-transplant history of gout had a higher risk of developing post-transplant gout than patients without (RR = 3.61; 95% CI: 2.19–5.95). Factors associated with gout and outcomes for heart and/or lung transplant recipients with gout were comprehensively reviewed from the included studies.</p></sec><sec><title>Conclusion</title><p>Gout is highly prevalent in heart and/or lung transplant patients. Pre-transplant gout is predictive of developing symptomatic post-transplant gout. This has significant implications for management of heart/lung transplant patients.</p></sec><sec><title>Systematic Review Registration</title><p><ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.crd.york.ac.uk/</ext-link>, PROSPERO (CRD42020190632).</p></sec>