AUTHOR=Cassano Alexandra , Chong Anita S. , Alegre Maria-Luisa 

TITLE=Tregs in transplantation tolerance: role and therapeutic potential

JOURNAL=Frontiers in Transplantation

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2023.1217065

DOI=10.3389/frtra.2023.1217065

ISSN=2813-2440

ABSTRACT=<p>CD4<sup>+</sup> Foxp3<sup>+</sup> regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and they play a role in cancer and transplantation settings by restraining immune responses. In this review, we describe evidence for the importance of Tregs in the induction versus maintenance of transplantation tolerance, discussing insights into mechanisms of Treg control of the alloimmune response. Further, we address the therapeutic potential of Tregs as a clinical intervention after transplantation, highlighting engineered CAR-Tregs as well as expansion of donor and host Tregs.</p>