AUTHOR=Knechtle Stuart , Kwun Jean , Song Shengli , Jackson Annette , Williams Kitza , Sanoff Scott TITLE=Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation JOURNAL=Frontiers in Transplantation VOLUME=2 YEAR=2023 URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2023.1176796 DOI=10.3389/frtra.2023.1176796 ISSN=2813-2440 ABSTRACT=

Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate model to modulate the B cell response to incompatible kidney transplants. After more than two decades of research supported by mechanistic studies, this has resulted in clinically relevant approaches that are currently enrolling in clinical trials or preparing for such. In this manner, we aim to address the problems of HLA sensitization for very highly sensitized patients awaiting transplantation and the unmet need of effective treatment for antibody-mediated rejection.