AUTHOR=Beath Sue V. , Taylor Zoe , Wray Jo , Passingham Charlotte , Lloyd Carla , Kelly Deirdre A. TITLE=Long-Term Cognitive Outcomes and Associated Quality of Life of Young Adults Who Experienced Liver Transplantation in Early Childhood JOURNAL=Frontiers in Transplantation VOLUME=1 YEAR=2022 URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2022.919232 DOI=10.3389/frtra.2022.919232 ISSN=2813-2440 ABSTRACT=
We evaluated long term outcomes in infants born between 1992 and 2002 with cholestatic liver disease (CLD) who underwent successful liver transplantation (LT). A total of 160 children with CLD were identified: 68 had developmental assessments before and after LT of whom 32 were excluded because they were followed up elsewhere; 16/36 consented to complete measures of IQ, anxiety, depression, health related quality of life (HRQoL), and a habits/employment survey. Illness severity and developmental attainment prior to LT were comparable with the 32 excluded and 20 patients who declined to take part. The IQ of young adults after LT (mean score = 91.13, range 75–108, SD 10.4) was not significantly improved compared to pre-LT scores (mean score = 85.7 range 50–111, SD 17), but was inversely correlated with stunting of growth and duration of disease before LT, highlighting the need for timely LT in CLD. HRQoL scores ranged from 22 to 99 (mean 64.5 SD 20.7), comparable to scores in other LT recipients. Five (31%) had mild-moderate depression; 5 (31%) had moderate-severe anxiety associated with reduced HRQoL (