AUTHOR=Belhoste Manon , Allenbach Gilles , Agius Thomas , Meier Raphael P. H. , Venetz Jean-Pierre , Corpataux Jean-Marc , Schneider Antoine , Golshayan Déla , Prior John O. , Déglise Sébastien , Nicod-Lalonde Marie , Longchamp Alban
TITLE=Role of post-transplant graft scintigraphy in kidney donation after circulatory death
JOURNAL=Frontiers in Transplantation
VOLUME=1
YEAR=2022
URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2022.1065415
DOI=10.3389/frtra.2022.1065415
ISSN=2813-2440
ABSTRACT=BackgroundThere is no consensus on how to predict post-transplant function of donation after circulatory death (DCD) kidneys. Thus, we aimed to identify renal scintigraphy parameters that could predict 1-year kidney function.
MethodsIn this single center study, we included all consecutive DCD kidney recipients between 2013 and 2021 (n = 29). Patients who did not have a scintigraphy within 10 days of transplantation (n = 3), recipients of multiple organs and less than 18 years old were excluded (n = 1). Primary endpoint was the estimated glomerular filtration rate (eGFR).
ResultsMedian eGFR and serum creatinine at 1 year were 67 µmol/L (56–81) and 111 ml/min (99–132), respectively. Among parameters tested, the 3rd/2nd-minute activity ratio had the best diagnostic performance (AUC: 0.74 and 0.71, for eGFR and creatinine) 1 year post transplantation. Using 1.21 as the best cut off, the 3rd/2nd-minute activity ratio specificity and sensitivity to predict eGFR >60 ml/min was 0.82 and 0.83. Renal function was significantly better at 1 week, 3, 6, and 12 months after transplantation in patients with 3rd/2nd-minute activity ratios above 1.21.
ConclusionThis study suggests that the 3rd/2nd-minute activity ratio can predict graft function at 1 year. The benefit of post-transplant scintigraphy should be further validated in a prospective cohort.