Frontiers in Toxicology

Brief Research Report

Accepted on 14 Mar 2025

Elucidating Mechanistic Relationships between Peroxisome Proliferator-activated Receptors and Hepatic Fibrosis using the ROBOKOP Knowledge Graph

in Computational Toxicology and Informatics

Karamarie Fecho
Nyssa Tucker
Jon-Michael Beasley
Scott Auerbach
Chris Bizon
Alexander Tropsha

Frontiers in Toxicology

doi 10.3389/ftox.2025.1549268

Original Research

Published on 14 Mar 2025

Selection of the critical effect size alters hazard characterization – a retrospective analysis of key studies used for risk assessments of PFAS

in Regulatory Toxicology

L. Brunken
A. Vieira Silva
M. Öberg

Frontiers in Toxicology

doi 10.3389/ftox.2025.1525089

642 views

Review

Published on 13 Mar 2025

Implications of petrochemical exposure and epigenetic alterations on human health

in Environmental Toxicology

Selvaraj Jayaraman
Anupriya Eswaran
Vishnu Priya Veeraraghavan
Mohammed Fazal
Adham Al-Rahbi
Srinivasa Rao Sirasanagandla

Frontiers in Toxicology

doi 10.3389/ftox.2025.1542871

858 views

Perspective

Published on 13 Mar 2025

Pesticides and public health: discussing risks in Brazilian agro-industrial growth

in Developmental and Reproductive Toxicology

Juliana E. Perobelli

Frontiers in Toxicology

doi 10.3389/ftox.2025.1442801

637 views

Original Research

Accepted on 11 Mar 2025

Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus)

in Environmental Toxicology

Bingbu Li
Guixing Wang
Xinyu Zheng
Mingyang Liu
Yucong Yang
Yuqin Ren
Yitong Zhang
Yufeng Liu
Zhongwei He
Jangong Ren

Frontiers in Toxicology

doi 10.3389/ftox.2025.1560192

Editorial

Published on 11 Mar 2025

Editorial: Chemical contaminants in natural environments and human health implications

in Environmental Toxicology

Aina Olubukola Adeogun
Azubuike Victor Chukwuka
Beatrice Olutoyin Opeolu
Oju Ibor
Ebenezer Olatunde Farombi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1528372

431 views

Original Research

Published on 06 Mar 2025

Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice

in Immunotoxicology

Victor J. Johnson
Cynthia V. Rider
Michael I. Luster
Cynthia J. Willson
Shawn Harris
Billie Stiffler
James Blake
Esra Mutlu
Veronica Godfrey
Brian Burback

Frontiers in Toxicology

doi 10.3389/ftox.2025.1558639

469 views

Case Report

Published on 27 Feb 2025

Case report: Pesticide-related methemoglobinemia: Tebufenozide and indoxacarb poisoning

in Clinical Toxicology

Jieru Wang
Guangcai Yu
Tianzi Jian
Baotian Kan
Wei Li
Xiangdong Jian

Frontiers in Toxicology

doi 10.3389/ftox.2025.1557990

386 views

Original Research

Published on 26 Feb 2025

Pattern, severity, and treatment outcomes in acute poisoning patients admitted to the Saint Peter Specialized Hospital Toxicology Center in Addis Ababa, Ethiopia, 2023: a retrospective study

in Clinical Toxicology

Yared Negussie Kebede
Abdurehman Seid Mohammed
Chekole Sileshi Menberu
Getachew Mekete Diress

Frontiers in Toxicology

doi 10.3389/ftox.2025.1517970

632 views

Review

Published on 26 Feb 2025

Comprehensive overview of the toxicities of small-molecule cryoprotectants for carnivorous spermatozoa: foundation for computational cryobiotechnology

in Developmental and Reproductive Toxicology

Isaac Karimi
Layth Jasim Mohammad
A. Suvitha
Zohreh Haidari
Helgi B. Schiöth

Frontiers in Toxicology

doi 10.3389/ftox.2025.1477822

1,057 views

Original Research

Published on 21 Feb 2025

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

in In Vitro Toxicology

Renato Ivan de Ávila
Iris Müller
Hugh Barlow
Alistair Mark Middleton
Mathura Theiventhran
Danilo Basili
Anthony M. Bowden
Ouarda Saib
Patrik Engi
Tymoteusz Pietrenko

Frontiers in Toxicology

doi 10.3389/ftox.2025.1426132

2,504 views

Original Research

Published on 21 Feb 2025

Evaluation of estrogenic and anti-estrogenic activity of endocrine disruptors using breast cancer spheroids: a comparative study of T47D and MCF7 cell lines in 2D and 3D models

in In Vitro Toxicology

Katia Barbaro
Elisa Innocenzi
Valentina Monteleone
Daniele Marcoccia
Annalisa Altigeri
Alessia Zepparoni
Daniela Caciolo
Cristian Alimonti
Marta Mollari
Paola Ghisellini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1547640

617 views

Original Research

Published on 19 Feb 2025

Comparing computational times for simulations when using PBPK model template and stand-alone implementations of PBPK models

in Computational Toxicology and Informatics

Amanda S. Bernstein
Paul M. Schlosser
Dustin F. Kapraun

Frontiers in Toxicology

doi 10.3389/ftox.2025.1518769

551 views

Editorial

Published on 18 Feb 2025

Editorial: Model organisms in toxicology

in Neurotoxicology

Michael Aschner
Asok K. Dasmahapatra
Arantza Muriana

Frontiers in Toxicology

doi 10.3389/ftox.2025.1560492

632 views

Original Research

Published on 12 Feb 2025

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

in In Vitro Toxicology

Tasnia Sharin
Doug Crump
Jason M. O’Brien

Frontiers in Toxicology

doi 10.3389/ftox.2025.1482865

480 views

Editorial

Published on 12 Feb 2025

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment

in In Vitro Toxicology

Marc Teunis
Thomas Luechtefeld
Thomas Hartung

Frontiers in Toxicology

doi 10.3389/ftox.2025.1568453

852 views