2023: A Retrospective Study

Getachew Mekete ^1* Yared Nigussie ² Abdurehman seid ² Chekole Sileshi ³

• ¹ Debre Tabor University, Gondar, Ethiopia
• ² Saint Peter Spesialized Hospital, Addis Ababa, Ethiopia
• ³ Saint Pater Spesialized Hospital, Addis Ababa, Ethiopia

Background: Poisoning is a major public health problem globally which has more unfavorable outcomes in developing countries. This study aimed to assess treatment outcomes and associated factors among poisoned patients treated at Saint Peter Specialized Hospital Toxicology Center. Methods: An institutional-based retrospective cohort study was employed by reviewing medical chart records of acutely poisoned patients who had been admitted at St. Peter Specialized Hospital Toxicology Center on 01/01/2017 to 30/12/2023 and the medical chart records review was employed from 1/01/20214 to 30/02/2024. This study analyzed records of 553 poisoned patients who were treated at Saint Peter Specialized Hospital Toxicology Center. A systematic random sampling technique was used to select the study unit. Data was entered and analyzed using Statistical Package for Social Sciences (SPSS) window version 26. A binary logistic regression model was used to identify associated factors for treatment outcomes of poisoned patients. A Pvalue < 0.05 was considered as statistically significant.Result: A total of 553 documents of poisoned patients were assessed, and the overall mortality rate was 18(3.25%) and 4 patients developed chronic complications. Factor analyses show that arrival to the center before 4 hours (AOR=0.43, P =0.008) predicted recovery. Whereas arrival at the toxicology center after 8 hours (AOR=2.21, P =0.004), being hypotensive (AOR=1.85, P=0.002), need intubation (AOR=2.52, P=0.014), and presence of two or more complication (AOR=3.3, P<0.001) at admission were predictors of mortality.The mortality rate for poisoned patients was 18 (3.25%). In this study, delayed arrival to the toxicology center, being hypotensive, the need for intubation, and the presence of two or more complications at admission were factors associated with the mortality and morbidity of the patients.Establishing a strong referral link between the toxicology center and regional health institution, ensuring the availability of possible advanced clinical setup early recognition, and aggressively resuscitating critically ill patients will help minimize unfavorable outcomes.