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REVIEW article

Front. Toxicol.
Sec. Regulatory Toxicology
Volume 6 - 2024 | doi: 10.3389/ftox.2024.1474792

Overview of human health effects related to glyphosate exposure

Provisionally accepted
Flavia S. Galli Flavia S. Galli 1Marta Mollari Marta Mollari 1Valentina Tassinari Valentina Tassinari 2Cristian Alimonti Cristian Alimonti 1Alessandro Ubaldi Alessandro Ubaldi 1Camilla Cuva Camilla Cuva 1*Daniele Marcoccia Daniele Marcoccia 1
  • 1 Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Rome, Italy
  • 2 Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy

The final, formatted version of the article will be published soon.

    Glyphosate is a chemical compound derived from glycine, marketed as a broad-spectrum herbicide, and represents one of the most widely used pesticides in the world. For a long time, it was assumed that glyphosate was harmless, either due to its selective enzymatic acting method on plants, and because commercial formulations were believed to contain only inert chemicals. Glyphosate is widely spread in the environment, the general population is daily exposed to it via different routes, including the consumption of both plant, and non-plant based foods. Glyphosate has been detected in high amounts in workers' urine, but has been detected likewise in bodily fluids of general population with an incidence rate of approximately 60-80 %, including childrenGlyphosate has been detected in high amounts in workers' urine, but has been detected likewise in bodily fluids, such as blood and maternal milk, and also in 60-80 % of general population, including children. Considering its massive presence, daily exposure to glyphosate could be considered a health risk for humans. Indeed, in 2015, the IARC (International Agency for Research on Cancer) classified glyphosate and its derivatives in Group 2A, as probable human carcinogens. In 2022, nevertheless, EFSA (European Food Safety Authority) stated that the available data did not provide sufficient evidence to prove the mutagenic/carcinogenic effects of glyphosate. Therefore, the European Commission (EC) decided to renew the approval of glyphosateGLY for another 10 years. The purpose of this review is to examine the scientific literature, focusing on potential risks to human health arising from exposure to glyphosate, its metabolites and its commercial products (e.g. Roundup®), with particular regard to its mutagenic and carcinogenic potential and its effects as endocrine disrupter (ED) especially in the human reproductive system.

    Keywords: glyphosate, Plant protection products, MUTAGENIC, Cancer, human health and reproduction

    Received: 05 Aug 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Galli, Mollari, Tassinari, Alimonti, Ubaldi, Cuva and Marcoccia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Camilla Cuva, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Rome, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.