AUTHOR=Ameh Thelma , Zarzosa Kuzy , Braswell W. Evan , Sayes Christie M. TITLE=Nanoparticle surface coatings produce distinct antibacterial effects that are consistent across diverse bacterial species JOURNAL=Frontiers in Toxicology VOLUME=5 YEAR=2023 URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2023.1119547 DOI=10.3389/ftox.2023.1119547 ISSN=2673-3080 ABSTRACT=
Nanoparticles have been proposed as tunable delivery vehicles for targeted treatments and, in some cases, the active therapeutic agents themselves. Despite the promise of such customizable impacts, little evidence exists to support these claims in the realm of antibiotics. Exploration of the silver and copper nanoparticle antibacterial impacts have been reported with inconsistent results. Here, we investigate the physical, chemical, and bacterial properties of silver and copper core particles stabilized with commonly used surface coatings, namely, polyvinylpyrrolidone (PVP, to confer a neutrally charged surface), cetrimonium bromide (CTAB, positively charged surface), citrate (Cit, negatively charged surface for silver nanoparticles), and ascorbic acid (AA, negatively charged surface for copper nanoparticles. The impacts of these potential antibacterial nanoparticles are measured against three bacterial species spanning deep divisions in the bacterial tree of life and include