AUTHOR=Lui Austin , Kumar Kevin K. , Grant Gerald A. 

TITLE=Management of Severe Traumatic Brain Injury in Pediatric Patients

JOURNAL=Frontiers in Toxicology

VOLUME=4

YEAR=2022

URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2022.910972

DOI=10.3389/ftox.2022.910972

ISSN=2673-3080

ABSTRACT=<p>The optimal management of severe traumatic brain injury (TBI) in the pediatric population has not been well studied. There are a limited number of research articles studying the management of TBI in children. Given the prevalence of severe TBI in the pediatric population, it is crucial to develop a reference TBI management plan for this vulnerable population. In this review, we seek to delineate the differences between severe TBI management in adults and children. Additionally, we also discuss the known molecular pathogenesis of TBI. A better understanding of the pathophysiology of TBI will inform clinical management and development of therapeutics. Finally, we propose a clinical algorithm for the management and treatment of severe TBI in children using published data.</p>