AUTHOR=Patlewicz Grace , Worth Andrew , Yang Chihae , Zhu Tingting TITLE=Editorial: Advances and Refinements in the Development and Application of Threshold of Toxicological Concern JOURNAL=Frontiers in Toxicology VOLUME=4 YEAR=2022 URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2022.882321 DOI=10.3389/ftox.2022.882321 ISSN=2673-3080