AUTHOR=Dai Wanqin , Zhang Junzhe , Wang Yun , Jiao Chunlei , Song Zhuda , Ma Yuhui , Ding Yayun , Zhang Zhiyong , He Xiao TITLE=Radiolabeling of Nanomaterials: Advantages and Challenges JOURNAL=Frontiers in Toxicology VOLUME=3 YEAR=2021 URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2021.753316 DOI=10.3389/ftox.2021.753316 ISSN=2673-3080 ABSTRACT=

Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the “last-step” labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed.