AUTHOR=Singh Radha Dutt , Koshta Kavita , Tiwari Ratnakar , Khan Hafizurrahman , Sharma Vineeta , Srivastava Vikas TITLE=Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health JOURNAL=Frontiers in Toxicology VOLUME=3 YEAR=2021 URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2021.663372 DOI=10.3389/ftox.2021.663372 ISSN=2673-3080 ABSTRACT=

Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime. Exposure to endocrine disrupting chemicals (EDCs) during fetal development can affect the hormone system homeostasis, resulting in a broad spectrum of adverse health outcomes. In the present review, we have described the effect of prenatal EDCs exposure on cardio-metabolic-renal health, using the available epidemiological and experimental evidence. We also discuss the potential mechanisms of their action, which include epigenetic changes, hormonal imprinting, loss of energy homeostasis, and metabolic perturbations. The effect of prenatal EDCs exposure on cardio-metabolic-renal health, which is a complex condition of an altered biological landscape, can be further examined in the case of other environmental stressors with a similar mode of action.