AUTHOR=Lowet Eric , De Weerd Peter , Roberts Mark J. , Hadjipapas Avgis TITLE=Tuning Neural Synchronization: The Role of Variable Oscillation Frequencies in Neural Circuits JOURNAL=Frontiers in Systems Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2022.908665 DOI=10.3389/fnsys.2022.908665 ISSN=1662-5137 ABSTRACT=

Brain oscillations emerge during sensory and cognitive processes and have been classified into different frequency bands. Yet, even within the same frequency band and between nearby brain locations, the exact frequencies of brain oscillations can differ. These frequency differences (detuning) have been largely ignored and play little role in current functional theories of brain oscillations. This contrasts with the crucial role that detuning plays in synchronization theory, as originally derived in physical systems. Here, we propose that detuning is equally important to understand synchronization in biological systems. Detuning is a critical control parameter in synchronization, which is not only important in shaping phase-locking, but also in establishing preferred phase relations between oscillators. We review recent evidence that frequency differences between brain locations are ubiquitous and essential in shaping temporal neural coordination. With the rise of powerful experimental techniques to probe brain oscillations, the contributions of exact frequency and detuning across neural circuits will become increasingly clear and will play a key part in developing a new understanding of the role of oscillations in brain function.