AUTHOR=Li Yong , Tiedemann Lasse , von Frieling Jakob , Nolte Stella , El-Kholy Samar , Stephano Flora , Gelhaus Christoph , Bruchhaus Iris , Fink Christine , Roeder Thomas TITLE=The Role of Monoaminergic Neurotransmission for Metabolic Control in the Fruit Fly Drosophila Melanogaster JOURNAL=Frontiers in Systems Neuroscience VOLUME=Volume 11 - 2017 YEAR=2017 URL=https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2017.00060 DOI=10.3389/fnsys.2017.00060 ISSN=1662-5137 ABSTRACT=
Hormones control various metabolic traits comprising fat deposition or starvation resistance. Here we show that two invertebrate neurohormones, octopamine (OA) and tyramine (TA) as well as their associated receptors, had a major impact on these metabolic traits. Animals devoid of the monoamine OA develop a severe obesity phenotype. Using flies defective in the expression of receptors for OA and TA, we aimed to decipher the contributions of single receptors for these metabolic phenotypes. Whereas those animals impaired in