Frontiers in Systems Biology

Review

Published on 07 Jan 2025

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions

Jun Sun
Masanori Aikawa
Hassan Ashktorab
Noam D. Beckmann
Michael L. Enger
Joaquin M. Espinosa
Xiaowu Gai
Benjamin D. Horne
Paul Keim
Jessica Lasky-Su

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1422384

1,193 views

Original Research

Published on 03 Jan 2025

Improvement in the prediction power of an astrocyte genome-scale metabolic model using multi-omic data

Andrea Angarita-Rodríguez
Nicolás Mendoza-Mejía
Janneth González
Jason Papin
Andrés Felipe Aristizábal
Andrés Pinzón

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1500710

469 views

Original Research

Published on 12 Dec 2024

Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysis

Mouly F. Rahman
Andre H. Kurlovs
Munender Vodnala
Elamaran Meibalan
Terry K. Means
Nima Nouri
Emanuele de Rinaldis
Virginia Savova

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1466368

938 views

Methods

Published on 18 Nov 2024

An exploration of testing genetic associations using goodness-of-fit statistics based on deep ReLU neural networks

Xiaoxi Shen
Xiaoming Wang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1460369

286 views

Mini Review

Published on 13 Nov 2024

Interplay of circular RNAs in gastric cancer - a systematic review

Dipanjan Guha
Jit Mondal
Anirban Nandy
Sima Biswas
Angshuman Bagchi

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1497510

361 views

Specialty Grand Challenge

Published on 06 Nov 2024

Bridging complexity through integrative systems neuroscience

Eric H. Chang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1487298

1,111 views

Original Research

Published on 15 Oct 2024

Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure

Ruben Zamora
Jinling Yin
Derek Barclay
James E. Squires
Yoram Vodovotz

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1470000

410 views

Methods

Published on 03 Oct 2024

Spectral expansion methods for prediction uncertainty quantification in systems biology

Anna Deneer
Jaap Molenaar
Christian Fleck

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1419809

542 views

Methods

Published on 12 Sep 2024

Building virtual patients using simulation-based inference

Nathalie Paul
Venetia Karamitsou
Clemens Giegerich
Afshin Sadeghi
Moritz Lücke
Britta Wagenhuber
Alexander Kister
Markus Rehberg

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1444912

986 views

Original Research

Published on 02 Sep 2024

Accessible Type 2 diabetes medication through stable expression of Exendin-4 in Saccharomyces cerevisiae

Gia Balius
Kiana Imani
Zoë Petroff
Elizabeth Beer
Thiago Brasileiro Feitosa
Nathan Mccall
Lauren Paule
Neo Yixuan Peng
Joanne Shen
Vidhata Singh

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1283371

1,619 views

Original Research

Published on 29 Aug 2024

A multi-scale semi-mechanistic CK/PD model for CAR T-cell therapy

Sarah Minucci
Scott Gruver
Kalyanasundaram Subramanian
Marissa Renardy

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1380018

1,681 views

Original Research

Published on 14 Aug 2024

First evidence for temperature’s influence on the enrichment, assembly, and activity of polyhydroxyalkanoate-synthesizing mixed microbial communities

Anna Trego
Tania Palmeiro-Sánchez
Alison Graham
Umer Zeeshan Ijaz
Vincent O’Flaherty

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1375472

988 views

Original Research

Published on 06 Aug 2024

Modeling uncertainty: the impact of noise in T cell differentiation

David Martínez-Méndez
Carlos Villarreal
Leonor Huerta

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1412931

747 views

Review

Published on 02 Aug 2024

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

Ben Noordijk
Monica L. Garcia Gomez
Kirsten H. W. J. ten Tusscher
Dick de Ridder
Aalt D. J. van Dijk
Robert W. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1407994

3,618 views
1 citation

Perspective

Published on 24 Jul 2024

Transporter annotations are holding up progress in metabolic modeling

John Casey
Brian Bennion
Patrik D’haeseleer
Jeffrey Kimbrel
Gianna Marschmann
Ali Navid

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1394084

1,359 views
1 citation

Perspective

Published on 17 Jul 2024

Life’s building blocks: the modular path to multiscale complexity

Saúl Huitzil
Cristián Huepe

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1417800

1,157 views

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Volumes

Volume 4 - 2024

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions

Improvement in the prediction power of an astrocyte genome-scale metabolic model using multi-omic data

Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysis

An exploration of testing genetic associations using goodness-of-fit statistics based on deep ReLU neural networks

Interplay of circular RNAs in gastric cancer - a systematic review

Bridging complexity through integrative systems neuroscience

Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure

Spectral expansion methods for prediction uncertainty quantification in systems biology

Building virtual patients using simulation-based inference

Accessible Type 2 diabetes medication through stable expression of Exendin-4 in Saccharomyces cerevisiae

A multi-scale semi-mechanistic CK/PD model for CAR T-cell therapy

First evidence for temperature’s influence on the enrichment, assembly, and activity of polyhydroxyalkanoate-synthesizing mixed microbial communities

Modeling uncertainty: the impact of noise in T cell differentiation

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

Transporter annotations are holding up progress in metabolic modeling

Life’s building blocks: the modular path to multiscale complexity