Frontiers in Systems Biology

Perspective

Published on 12 Jul 2024

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its pAIns and gAIns

in Translational Systems Biology and In Silico Trials

Núria Folguera-Blasco
Florencia A. T. Boshier
Aydar Uatay
Cesar Pichardo-Almarza
Massimo Lai
Jacopo Biasetti
Richard Dearden
Megan Gibbs
Holly Kimko

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1380685

1,963 views

Original Research

Published on 04 Jul 2024

Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

in Translational Systems Biology and In Silico Trials

John S. Clemmer
W. Andrew Pruett
Robert L. Hester

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1327357

880 views
1 citation

Technology and Code

Published on 17 Jun 2024

PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered in silico vaccine candidate against COVID-19

in Translational Systems Biology and In Silico Trials

Javier Uzcátegui
Khaleel Mullah
Daniel Buvat de Virgini
Andrés Mendoza
Rafael Urdaneta
Alejandra Naranjo

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1309891

1,379 views

Specialty Grand Challenge

Published on 17 Jun 2024

Specialty grand challenge: how can we use integrative approaches to understand microbial community dynamics?

in Integrative Systems Microbiology

Umer Zeeshan Ijaz
Aqsa Ameer
Farrukh Saleem
Farzana Gul
Ciara Keating
Sundus Javed

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1432791

1,257 views
2 citations

Original Research

Published on 07 Jun 2024

Building an Adverse Outcome Pathway network for COVID-19

in Systems and Synthetic Immunology

Penny Nymark
Laure-Alix Clerbaux
Maria-João Amorim
Christos Andronis
Francesca de Bernardi
Gillina F. G. Bezemer
Sandra Coecke
Felicity N. E. Gavins
Daniel Jacobson
Eftychia Lekka

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1384481

949 views

Mini Review

Published on 03 Jun 2024

De novo prediction of functional effects of genetic variants from DNA sequences based on context-specific molecular information

in Integrative Genetics and Genomics

Jiaxin Yang
Sikta Das Adhikari
Hao Wang
Binbin Huang
Wenjie Qi
Yuehua Cui
Jianrong Wang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1402664

1,336 views

Original Research

Published on 30 May 2024

Surface-displayed silicatein-α enzyme in bioengineered E. coli enables biocementation and silica mineralization

in Data and Model Integration

Toriana N. Vigil
Nikolas K. Schwendeman
Melanie L. M. Grogger
Victoria L. Morrison
Margaret C. Warner
Nathaniel B. Bone
Morgan T. Vance
David C. Morris
Kristi McElmurry
Bryan W. Berger

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1377188

1,693 views

Review

Published on 29 Apr 2024

Crosstalking with dendritic cells: a path to engineer advanced T Cell immunotherapy

in Systems and Synthetic Immunology

Sogand Schafer
Kaige Chen
Leyuan Ma

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1372995

2,378 views

Original Research

Published on 25 Apr 2024

Elucidating a genomic signature associated with behavioral and executive function after moderate to severe pediatric TBI: a systems biology informed approach

in Integrative Genetics and Genomics

Brad G. Kurowski
Amery Treble-Barna
Valentina Pilipenko
Lisa J. Martin
Anil G. Jegga
Aimee E. Miley
Nanhua Zhang
Anthony Fabio
Ranjit S. Chima
Anna-Lynne R. Adlam

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1293265

918 views

Technology and Code

Published on 18 Apr 2024

Context-aware knowledge selection and reliable model recommendation with ACCORDION

in Data and Model Integration

Yasmine Ahmed
Cheryl A. Telmer
Gaoxiang Zhou
Natasa Miskov-Zivanov

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1308292

782 views
2 citations

Review

Published on 09 Apr 2024

A review of mathematical modeling of bone remodeling from a systems biology perspective

in Multiscale Mechanistic Modeling

Carley V. Cook
Ariel M. Lighty
Brenda J. Smith
Ashlee N. Ford Versypt

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1368555

2,609 views
2 citations

Original Research

Published on 09 Apr 2024

Forecasting SARS-CoV-2 spike protein evolution from small data by deep learning and regression

in Data and Model Integration

Samuel King
Xinyi E. Chen
Sarah W. S. Ng
Kimia Rostin
Samuel V. Hahn
Tylo Roberts
Janella C. Schwab
Parneet Sekhon
Madina Kagieva
Taylor Reilly

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1284668

2,664 views

Perspective

Published on 03 Apr 2024

Is there room in epilepsy for the claustrum?

in Integrative Systems Neuroscience

Glenn D. R. Watson
Stefano Meletti
Anil K. Mahavadi
Pierre Besson
S. Kathleen Bandt
Jared B. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1385112

1,336 views

Original Research

Published on 03 Apr 2024

Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy

in Translational Systems Biology and In Silico Trials

Quim Martí-Baena
Andreu Pascuet-Fontanet
Tomas Berjaga-Buisan
Miriam Caravaca-Rodríguez
Jaume Puig-Costa-Jussà
Avencia Sanchez-Mejias
Dimitrije Ivančić
Sira Mogas-Díez
Marc Güell
Javier Macia

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1270071

1,780 views

Original Research

Published on 27 Mar 2024

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

in Data and Model Integration

Rayna M. Nolen
Lene H. Petersen
Karl Kaiser
Antonietta Quigg
David Hala

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1367562

898 views
1 citation

Original Research

Published on 25 Mar 2024

Mathematical modeling of temperature-induced circadian rhythms

in Translational Systems Biology and In Silico Trials

Lingjun Lu
Yannuo Li
Rene Schloss
Ioannis P. Androulakis

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1256398

1,278 views
1 citation

Navigation group

Articles

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its pAIns and gAIns

Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered in silico vaccine candidate against COVID-19

Specialty grand challenge: how can we use integrative approaches to understand microbial community dynamics?

Building an Adverse Outcome Pathway network for COVID-19

De novo prediction of functional effects of genetic variants from DNA sequences based on context-specific molecular information

Surface-displayed silicatein-α enzyme in bioengineered E. coli enables biocementation and silica mineralization

Crosstalking with dendritic cells: a path to engineer advanced T Cell immunotherapy

Elucidating a genomic signature associated with behavioral and executive function after moderate to severe pediatric TBI: a systems biology informed approach

Context-aware knowledge selection and reliable model recommendation with ACCORDION

A review of mathematical modeling of bone remodeling from a systems biology perspective

Forecasting SARS-CoV-2 spike protein evolution from small data by deep learning and regression

Is there room in epilepsy for the claustrum?

Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

Mathematical modeling of temperature-induced circadian rhythms