AUTHOR=Guha Dipanjan , Mondal Jit , Nandy Anirban , Biswas Sima , Bagchi Angshuman 

TITLE=Interplay of circular RNAs in gastric cancer - a systematic review

JOURNAL=Frontiers in Systems Biology

VOLUME=4

YEAR=2024

URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2024.1497510

DOI=10.3389/fsysb.2024.1497510

ISSN=2674-0702

ABSTRACT=<p>Circular RNAs (circRNAs) have gained prominence as important players in various biological processes such as gastric cancer (GC). Identification of several dysregulated circRNAs may serve as biomarkers for early diagnosis or as novel therapeutic targets. Predictive models can suggest potential new interactions and regulatory roles of circRNAs in GCs. Experimental validations of key interactions are being performed using <italic>in vitro</italic> models, confirming the significance of identified circRNA networks. The aim of this review is to highlight the important circRNAs associated with GC. On top of that an overview of the mechanistic details of the biogenesis and functionalities of the circRNAs are also presented. Furthermore, the potentialities of the circRNAs in the field of new drug discovery are deciphered.</p>