AUTHOR=Densil Amanda , George Mya Elisabeth , Mahdi Hala , Chami Andrew , Mark Alyssa , Luo Chantal , Wang Yifan , Ali Aribah , Tang Pengpeng , Dong Audrey Yihui , Pao Sin Yu , Suri Rubani Singh , Valentini Isabella , Al-Arabi Lila , Liu Fanxiao , Singh Alesha , Wu Linda , Peng Helen , Sudharshan Anjana , Naqvi Zoha , Hewitt Jayda , Andary Catherine , Leung Vincent , Forsythe Paul , Xu Jianping TITLE=The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory JOURNAL=Frontiers in Systems Biology VOLUME=3 YEAR=2023 URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2023.1274184 DOI=10.3389/fsysb.2023.1274184 ISSN=2674-0702 ABSTRACT=
The diagnostic process for psychiatric conditions is guided by the Diagnostic and Statistical Manual of Mental Disorders (DSM) in North America. Revisions of the DSM over the years have led to lowered diagnostic thresholds across the board, incurring increased rates of both misdiagnosis and over-diagnosis. Coupled with stigma, this ambiguity and lack of consistency exacerbates the challenges that clinicians and scientists face in the clinical assessment and research of mood disorders such as Major Depressive Disorder (MDD). While current efforts to characterize MDD have largely focused on qualitative approaches, the broad variations in physiological traits, such as those found in the gut, suggest the immense potential of using biomarkers to provide a quantitative and objective assessment. Here, we propose the development of a probiotic