AUTHOR=Sommariva Sara , Berra Silvia , Biddau Giorgia , Caviglia Giacomo , Benvenuto Federico , Piana Michele 

TITLE=In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy

JOURNAL=Frontiers in Systems Biology

VOLUME=Volume 3 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2023.1207898

DOI=10.3389/fsysb.2023.1207898

ISSN=2674-0702

ABSTRACT=Chemical reaction networks are powerful tools for describing the complex nature of cancer's onset, progression, and therapy. The main reason for their effectiveness is in the fact that these networks can be rather naturally encoded as a dynamical system whose asymptotic solution mimics the proteins' concentration profile at equilibrium. The paper relies on this mathematical approach to investigate global and local effects on the chemical reaction network of the colorectal cancer, triggered by partial and complete mutations occurring in its mitogen-activated protein kinase (MAPK) pathway. Further, this same approach allowed the in-silico modelling and dosage of a multi-target therapeutic intervention that utilizes MAPK as its molecular target.