AUTHOR=Bai Dongsheng , Zhu Chenxu TITLE=Single-cell technologies for multimodal omics measurements JOURNAL=Frontiers in Systems Biology VOLUME=3 YEAR=2023 URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2023.1155990 DOI=10.3389/fsysb.2023.1155990 ISSN=2674-0702 ABSTRACT=

The recent surge in single-cell genomics, including the development of a wide range of experimental and computational approaches, has provided insights into the complex molecular networks of cells during development and in human diseases at unprecedented resolution. Single-cell transcriptome analysis has enabled high-resolution investigation of cellular heterogeneity in a wide range of cell populations ranging from early embryos to complex tissues—while posing the risk of only capturing a partial picture of the cells’ complex molecular networks. Single-cell multiomics technologies aim to bridge this gap by providing a more holistic view of the cell by simultaneously measuring multiple molecular types from the same cell and providing a more complete view of the interactions and combined functions of multiple regulatory layers at cell-type resolution. In this review, we briefly summarized the recent advances in multimodal single-cell technologies and discussed the challenges and opportunities of the field.