AUTHOR=Reynoso-García Jelissa , Miranda-Santiago Angel E. , Meléndez-Vázquez Natalie M. , Acosta-Pagán Kimil , Sánchez-Rosado Mitchell , Díaz-Rivera Jennifer , Rosado-Quiñones Angélica M. , Acevedo-Márquez Luis , Cruz-Roldán Lorna , Tosado-Rodríguez Eduardo L. , Figueroa-Gispert María Del Mar , Godoy-Vitorino Filipa TITLE=A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration JOURNAL=Frontiers in Systems Biology VOLUME=2 YEAR=2022 URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2022.951403 DOI=10.3389/fsysb.2022.951403 ISSN=2674-0702 ABSTRACT=

Humans are supra-organisms co-evolved with microbial communities (Prokaryotic and Eukaryotic), named the microbiome. These microbiomes supply essential ecosystem services that play critical roles in human health. A loss of indigenous microbes through modern lifestyles leads to microbial extinctions, associated with many diseases and epidemics. This narrative review conforms a complete guide to the human holobiont—comprising the host and all its symbiont populations- summarizes the latest and most significant research findings in human microbiome. It pretends to be a comprehensive resource in the field, describing all human body niches and their dominant microbial taxa while discussing common perturbations on microbial homeostasis, impacts of urbanization and restoration and humanitarian efforts to preserve good microbes from extinction.