AUTHOR=An Gary , Cockrell Chase TITLE=Drug Development Digital Twins for Drug Discovery, Testing and Repurposing: A Schema for Requirements and Development JOURNAL=Frontiers in Systems Biology VOLUME=2 YEAR=2022 URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2022.928387 DOI=10.3389/fsysb.2022.928387 ISSN=2674-0702 ABSTRACT=

There has been a great deal of interest in the concept, development and implementation of medical digital twins. This interest has led to wide ranging perceptions of what constitutes a medical digital twin. This Perspectives article will provide 1) a description of fundamental features of industrial digital twins, the source of the digital twin concept, 2) aspects of biology that challenge the implementation of medical digital twins, 3) a schematic program of how a specific medical digital twin project could be defined, and 4) an example description within that schematic program for a specific type of medical digital twin intended for drug discovery, testing and repurposing, the Drug Development Digital Twin (DDDT).