AUTHOR=Karr Jonathan , Malik-Sheriff Rahuman S. , Osborne James , Gonzalez-Parra Gilberto , Forgoston Eric , Bowness Ruth , Liu Yaling , Thompson Robin , Garira Winston , Barhak Jacob , Rice John , Torres Marcella , Dobrovolny Hana M. , Tang Tingting , Waites William , Glazier James A. , Faeder James R. , Kulesza Alexander TITLE=Model Integration in Computational Biology: The Role of Reproducibility, Credibility and Utility JOURNAL=Frontiers in Systems Biology VOLUME=2 YEAR=2022 URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2022.822606 DOI=10.3389/fsysb.2022.822606 ISSN=2674-0702 ABSTRACT=

During the COVID-19 pandemic, mathematical modeling of disease transmission has become a cornerstone of key state decisions. To advance the state-of-the-art host viral modeling to handle future pandemics, many scientists working on related issues assembled to discuss the topics. These discussions exposed the reproducibility crisis that leads to inability to reuse and integrate models. This document summarizes these discussions, presents difficulties, and mentions existing efforts towards future solutions that will allow future model utility and integration. We argue that without addressing these challenges, scientists will have diminished ability to build, disseminate, and implement high-impact multi-scale modeling that is needed to understand the health crises we face.