AUTHOR=Larson Julia L. , Robertson Henry T. , Grey Scott F. , Schobel Seth A. , Potter Benjamin K. , Elster Eric A. 

TITLE=Acute respiratory distress syndrome and acute lung injury in a trauma population with and without long bone fractures

JOURNAL=Frontiers in Systems Biology

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2022.1058603

DOI=10.3389/fsysb.2022.1058603

ISSN=2674-0702

ABSTRACT=<p><bold>Introduction:</bold> Trauma is the leading cause of death in persons under the age of 45. Recovery in patients who survive initial trauma are frequently complicated by sequelae of injury that increases susceptibility to infection and inflammation. Uncontrolled inflammation can advance into life-threatening organ failure, including acute respiratory distress syndrome (ARDS). Similarities exist between biomarkers established in the etiology of acute respiratory distress syndrome and those identified in the acute inflammatory and healing phase of bone fractures. This study investigates the impact of long bone fractures on the development of acute respiratory distress syndrome where it is hypothesized that patients with long bone fractures would have different biomarker profiles and increased development of lung injury compared to patients without long bone fractures.</p><p><bold>Methods</bold>: This is a retrospective data analysis of patients from an observational data repository from three trauma centers. Trauma patients with and without long bone fractures were matched and analyzed for the presence of known biomarkers of acute respiratory distress syndrome and for the development of acute respiratory distress syndrome.</p><p><bold>Results</bold>: There were no differences in overall acute respiratory distress syndrome development or hospital outcomes, however long bone fracture patients had a 2.35-fold higher hazard ratio of acute respiratory distress syndrome in the first 10 hospital days. There was a statistically significant increase in the levels of IL-6 in patients with long bone fractures (<italic>p</italic> = .0007). Structural equations modeling demonstrated that IL-6 was positively influenced by long bone fractures and IL-8.</p><p><bold>Conclusion</bold>: The presence of long bone fractures did not result in differences in the overall development of acute respiratory distress syndrome or hospital outcomes, though was found to have an increased hazard ratio for acute respiratory distress syndrome development in the first 10 days. Further research is needed to better characterize the relationship between varying cytokine profiles and the development of acute respiratory distress syndrome in a trauma population.</p>