AUTHOR=Piao Chengji , Sigrist Stephan J. TITLE=(M)Unc13s in Active Zone Diversity: A Drosophila Perspective JOURNAL=Frontiers in Synaptic Neuroscience VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2021.798204 DOI=10.3389/fnsyn.2021.798204 ISSN=1663-3563 ABSTRACT=
The so-called active zones at pre-synaptic terminals are the ultimate filtering devices, which couple between action potential frequency and shape, and the information transferred to the post-synaptic neurons, finally tuning behaviors. Within active zones, the release of the synaptic vesicle operates from specialized “release sites.” The (M)Unc13 class of proteins is meant to define release sites topologically and biochemically, and diversity between Unc13-type release factor isoforms is suspected to steer diversity at active zones. The two major Unc13-type isoforms, namely, Unc13A and Unc13B, have recently been described from the molecular to the behavioral level, exploiting