AUTHOR=Park Pojeong , Kang Heather , Sanderson Thomas M. , Bortolotto Zuner A. , Georgiou John , Zhuo Min , Kaang Bong-Kiun , Collingridge Graham L. 

TITLE=The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus

JOURNAL=Frontiers in Synaptic Neuroscience

VOLUME=10

YEAR=2018

URL=https://www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2018.00042

DOI=10.3389/fnsyn.2018.00042

ISSN=1663-3563

ABSTRACT=<p>Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.</p>