AUTHOR=Lalanne Txomin , Oyrer Julia , Farrant Mark , Sjöström P. Jesper 

TITLE=Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors

JOURNAL=Frontiers in Synaptic Neuroscience

VOLUME=10

YEAR=2018

URL=https://www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2018.00034

DOI=10.3389/fnsyn.2018.00034

ISSN=1663-3563

ABSTRACT=<p>Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.</p>