AUTHOR=Neher Erwin TITLE=What is Rate-Limiting during Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites JOURNAL=Frontiers in Synaptic Neuroscience VOLUME=2 YEAR=2010 URL=https://www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2010.00144 DOI=10.3389/fnsyn.2010.00144 ISSN=1663-3563 ABSTRACT=

For some types of synapses the availability of release-ready vesicles is a limiting factor during ongoing activity. Synaptic strength in this case is determined both by the recruitment of such vesicles and the probability of their release during an action potential. Here it is argued that not the availability of vesicles is the limiting factor for recruitment, but rather the availability of specific sites to which vesicles can dock.