Marco Giustra1†
Federico Cerri2†
Yaprak Anadol3
Lucia Salvioni1Tatiana Antonelli Abella4
Davide Prosperi1
Paolo Galli2,3,5‡
Miriam Colombo1*‡- 1NanoBioLab, Department of Biotechnology and Bioscience, University of Milano Bicocca, Milan, Italy
- 2Department of Earth and Environmental Sciences, University of Milano Bicocca, Milan, Italy
- 3Dubai Business School, University of Dubai, Dubai, United Arab Emirates
- 4Goumbook, Ras Al Khaimah, United Arab Emirates
- 5MaRHE Centre (Marine Research and High Education Center), Magoodhoo Island, Maldives
Climate change associated with global warming is a major warning of the twenty-first century, threatening ecosystems through uncontrolled temperature rises, drought, lack of water with a strong impact on productivity, economy, and worldwide life well-being. In most cases, the poor regions of the planet suffer from a lack of exploitable resources deriving from natural reserves. For this reason, wild vegetables able to grow in deserted areas are attracting increasing attention due to their beneficial properties. Among them, Prosopis cineraria has been recently recognized in the UAE not only as a cultural heritage but also as a potential source of raw materials for agri-food and pharmaceutics still poorly valued. P. cineraria occurs in most of the world's hot arid and semi-arid regions as a native or introduced species and, due to its multiple properties, could be exploited for medical, food, and, more recently, in different growing productivity fields like a luxury, especially in countries like the UAE. The use of actives-rich natural sources offers clear advantages over synthetic compounds in terms of process and product eco-sustainability. In this manuscript, we review the main properties and potential applications of P. cineraria aiming to promote the scientific interest toward the development of innovative approaches in several productive fields, including pharma and cosmetics, exploiting the versatility of materials that can be extracted from the various parts of the plant and discuss commercialization opportunities of the plant to support biodiversity and sustainability. In conclusion, P. cineraria turns out to be a plant able to grow in hostile environments, already providing nutrients for populations of Western Asia and the Indian subcontinent and possibly translatable to poor arid regions.
Introduction
In 1999, United Arab Emirates (UAE) became a member of the United Nations Convention to Combat Desertification (UNCCD), with a National Environmental Strategy to demonstrate its commitment to this convention (Al-Yamani et al., 2019). As one of the native trees of UAE that is a true survivor in the face of fiery temperatures, searing winds, and harsh desert conditions, in 2008, the Ghaf tree (i.e., Prosopis cineraria) has been declared the national tree of the UAE, and as a historical and cultural symbol, in 2019 it was used as the symbol of year of tolerance, representing the stability and peace in the UAE's desert environment (Jongbloed et al., 2003; EAD, 2019). Nowadays, P. cineraria occurs in most of the world's hot arid and semi-arid regions as a native or introduced species (Pasiecznik et al., 2001). Historically, the Ghaf tree has been integrated into many ways to traditional lifestyles in Asian countries as a natural remedy for various conditions and illnesses (Khatri et al., 2010; Janbaz et al., 2012; Afifi and Al-rub, 2018). Apart from remedial usage, the leaves and pods of the Ghaf tree are used for traditional cooking, and as fodder, its flowers are found good source for honey production while the canopy of the tree functions as a shelter for the wildlife and improves the micronutrients on the desert terrain (Kumar et al., 2011; Afifi and Al-rub, 2018).
The multifaceted potential of the Prosopis plant family
Prosopis is a genus of plant that belongs to the family Fabaceae (Leguminosae) (sub. family Mimosaceae) and comprises 44 known species, three of them native to Asia, one to Africa, and the others to America (González-Montemayor et al., 2019). Prosopis species are one of the major sources of proteins in arid and semi-arid regions as well as a good source of carbohydrates, lipids, minerals, and phytochemical compounds with beneficial effects on health (Afifi and Al-rub, 2018). Prosopis pods constitute a food source for humans and animals of the Monte desert as well as they are important nutrition sources for Amerindians in the Paraguayan Chaco and Chile. Different food products are made from Prosopis species: drinks (añapa, aloja, and chichi), syrup, flour, and sweets (arrope, patay, and jam) (Pérez et al., 2014). The beverage known as “anapa” is produced by mixing its pods in water, while after being fermented, it produces the alcoholic beverage “chichi” (Henciya et al., 2017).
Prosopis species have been used as a folk indigenous medicine for various ailments. The barks are dry, acrid, and bitter, with a sharp taste and cure leprosy, dysentery, asthma, leukoderma, tremors of the muscle, and wandering of the mind, while its ashes are rubbed over the skin to remove hair. Besides, the pounded flowers are mixed with sugar and used during pregnancy as protection against miscarriage; the smoke of the leaves is good for eye infections, and extracts are recommended against snakebite and scorpion sting, while fresh leaves juice mixed with lemon juice is used for dyspepsia; the extract of crushed pods is used for earache, toothache, and pain relief from fractured bones; the aqueous extract of bark and leaves is used to cure mouth and throat infections, bronchitis, ulcers, internal diseases including parasites and urinary diseases as well as applied externally to treat skin disease, disinfect wounds, and promote healing (Garg and Mittal, 2013; Henciya et al., 2017). Moreover, in Argentinean traditional medicine, Prosopis fruit is used as a sedative, and in pathologies associated with inflammatory processes like asthma and bronchitis (Carrizo et al., 2002). Several studies supported by advanced scientific technologies have demonstrated Prosopis pharmacological properties, including antioxidant, hepatoprotective, hemolytic, anticancer, antibacterial, antifungal, antidiabetic, and anti-inflammatory activities (Henciya et al., 2017).
People from the United States, Mexico, Peru, Bolivia, Chile, Paraguay, and Argentina have exploited this plant for their survival also because it has important economic value as a source of fuel and fodder, in charcoal production, and as construction material (González-Montemayor et al., 2019). Since its wood is extremely hard and durable and has an attractive coloration, it is used for making furniture and parquet floors (Henciya et al., 2017). Furthermore, due to its high carbohydrate content, attention has been paid to the potential of pods as a source of biofuels by processing the carbohydrates into ethanol and preliminary tests converted up to 80% of pods carbohydrates into bioethanol (Pasiecznik et al., 2001).
Prosopis cineraria: Geographic distribution, economic, and ecological importance
Prosopis cineraria is a thorny, irregularly branched flowering evergreen tree with a small-to-moderate size, mainly found in the regions of Arabia and India (Garg and Mittal, 2013). Different names are given to the P. cineraria: in India is called “Khejri” or “Kalpavriksha” (Kumar et al., 2019), “Jand” in Pakistan, and “Ghaf” in Arabic (Malik et al., 2013).
As xerophyte, P. cineraria can grow in arid and semi-arid regions, tolerates extreme temperatures (Lee and Felker, 1992 and González-Montemayor et al., 2019) it is described as an aridity-loving tree because in drought conditions it produces more flowers and fruits. The rooting can be very deep so that the tap root can penetrate up to 35-m deep vertically. This guarantees a stable base and a supply of water from the deep layers of soil, allowing the tree to withstand the hottest winds and the long dry season. Besides, it can also tolerate frost and a temperature < 10 °C during the winter season. The tree can grow on soils of different natures but develops better on alluvial soils made up of various mixtures of sand and clay (Khatri et al., 2010).
Prosopis cineraria tree makes a noteworthy contribution to the farm economy and rural area development and has been appreciated for the versatility of all its parts (Afifi and Al-rub, 2018) to the point of being named “the Wonder Tree” or “the King of Desert” [United States National Academy of Sciences (USNAS), 1980] or “the Golden Tree of Indian deserts” (Liu et al., 2012). Prosopis cineraria is a natural source of fuel and fodder in the arid regions of India and represents a good quality wood resource for basic construction for people in desert regions. However, in the global market, this plant's economic importance remains severely limited; for this reason, it has been neglected by researchers and industry (González-Montemayor et al., 2019).
Ecologically, it has the role of preventing soil erosion and dune stabilization thanks to its deep mass root system. It is adapted to survive in highly saline and alkaline soils, and it is grown aside from the millet crop as an atmospheric nitrogen fixer (Anand et al., 2017). Moreover, Litterfall production and decomposition rate are the highest compared to other trees growing in arid climates. Farmers tend to cultivate the fields under its canopy as this increases the growth and productivity of their crops. In fact, P. cineraria accumulates organic matter in the soil reaching the soluble calcium and phosphorus available and reducing the pH of the soil. Also, P. cineraria is largely used to produce feed as the leaves and pods are eaten by camels, cattle, sheep, and goats (Afifi and Al-rub, 2018). Finally, due to its long and abundant flowering, it is one of the most important plants for bee foraging in the Persian Gulf and the honey produced is of good quality (Sajwani et al., 2014).
Medical properties
Different uses of P. cineraria as a traditional medicine to treat various diseases were reported. In particular, the oral or topical administration of its leaves, stems, fruits, flowers, barks, and pods is used in different regions of Pakistan for the treatment of spasms, diabetes, liver infection, diarrhea, bladder and pancreas stones, fever, flu, rheumatism, leucorrhea, boils, blisters, scorpion bite, chronic dysentery, cataract, asthma, sexually transmitted infections, and gynecological complaints. It has also been reported that the beneficial effects of this plant have been exploited in the South of Kerman in Iran as an anti-asthma and against skin rashes (Sharifi-Rad et al., 2019).
The acute and subacute toxicity of P. cineraria hydroalcoholic extracts from leaves (PCL) and stem bark (PCB) was evaluated in Wistar rats after ingestion both in acute and subacute modes. Extracts did not produce significant changes in behavior, breathing, cutaneous effects, sensory nervous system responses, and gastrointestinal effects in rats and no mortality occurred in acute toxicity studies (Robertson et al., 2012). The toxicity profile parameters were studied and revealed that the administration of P. cineraria bark produced no adverse effects on general behavior and metabolism (Purohit and Ram, 2012). Many in vitro and in vivo biological activities were attributed to P. cineraria, and a wide variety of preclinical studies were carried out using this plant. The main pharmacological activities and relevant medical applications are summarized in Table 1.
Table 1. Prosopis cineraria main medical applications.
Toward eco-sustainable luxury products
In recent years, consumer demand for utilizing natural botanical sources in cosmetics has grown substantially due to fewer side effects, high efficiency, and easy availability (Ng et al., 2022). Therefore, research shifted toward natural products with the difficult attempt to formulate stable topical emulsions containing natural bioactive constituents. The instability of the preparation is one of the reasons why the cosmetic properties of P. cineraria such as skincare and anti-age have been poorly studied. An attempt was made by Mohammad et al. (2015) to formulate stable W/O emulsion cream loaded with a 2% preconcentrated P. cineraria extract. The cream's cosmetic potential was compared to the base (without extract) through its application to healthy human volunteers. The results showed that the formulation cream was stable, preventing color change, liquefaction, and phase separation, and the pH of the cream was in accordance with the normal skin pH range. Therefore, according to the results obtained by the panel test, it was clear that the formulation cream had optimal characteristics to be used cosmetically. However, further in vivo research was needed to investigate its cosmetic effects on human skin. Therefore, again Mohammad et al. (2018) investigated the emulsion in vivo by using a non-invasive probe cutometer and elastomer. The results displayed that this formulation (size 3 μm) decreased the skin melanin, erythema, and sebum contents up to 2.1–2.7 and 79% while increasing the skin hydration and elasticity up to two-folds and 22% as compared to the base formulation, respectively. Owing to enhanced therapeutic activity, the phytocosmetic formulation proved to be a potential skin whitening, moisturizer, anti-acne, anti-wrinkle, and anti-aging therapy and could actively induce skin rejuvenation and resurfacing.
An attempt to formulate an herbal depilatory cream containing leaves of P. cineraria was made by Verma et al. (2011). Leaves of P. cineraria and some other medicinal plants were added together with common ingredients of a cream base, i.e., calcium carbonate, cetyl alcohol, calcium hydroxide, liquid paraffin, water, and perfume. The depilatory activity was evaluated using mice. The hair growth inhibition test displayed that the effects of depilatory cream (typically over 3 weeks) gave unequivocal evidence of depilation: regrowth began on the ventral body surface 14–15 days after the last dose of depilatory cream. Besides, the evaluation of the test on depilation resistance on the back of mice resulted in a weight ratio of depilated hair of 200% compared to the control group suggesting that the depilatory cream reduced the amount and impairs the robustness of undesired hair reducing the need for depilation sessions. The authors concluded that the herbal depilatory cream was successfully developed using leaves of P. cineraria.
Prosopis cineraria components reclaim beneficial biological activities
As previously stated, P. cineraria can be exploited for numerous applications and none of the portions that make up the plant is discarded, but each one gives important pharmacological and cosmetic properties to the extracts for these uses. The presence of phytomolecules is promising in the synthesis of cosmetic formulations (Verma et al., 2011; Mohammad et al., 2015, 2018; Sharifi-Rad et al., 2019). As mentioned above, most articles explain the effectiveness of the phytochemicals in Ghaf as antioxidants or for other pharmaceutical applications (Abdul et al., 2012; Mohammad et al., 2013; Jain and Surana, 2015; Afifi and Al-rub, 2018; Kulshreshtha et al., 2019; Sharifi-Rad et al., 2019; Ansari et al., 2021; Bhardwaj and Al Khaimah, 2021; Akhtar et al., 2022; Zhong et al., 2022). In contrast, in cosmetics, the literature is still poor, and formulations may contain substances, such as PEG or liquid paraffin, which are not appreciated (Verma et al., 2011; Mohammad et al., 2015, 2018). In fact, from a careful global perspective on sustainability, new raw materials should be exploited to satisfy the customers in the choice of specific products referring to INCI (International Nomenclature of Cosmetic Ingredients), which allows them to know the ingredients of cosmetic formulations. Most of the molecules, in Prosopis, are classified as good or biocompatible according to the INCI, as reported in detail in Table 2.
Table 2. Formulation effect of the principal compounds in P. cineraria according to INCI.
In principle, all the main components are appealing to avail substances obtainable from P. cineraria:
• Seeds: 25–35 per pod, have a rhomboid or oblong shape, and are brown. Many molecules can be extracted from these seeds (Gangal et al., 2009; Garg and Mittal, 2013; Pareek et al., 2015; Afifi and Al-rub, 2018; Imam et al., 2019), including oils and actives. Indeed, both saturated and unsaturated fatty acids such as oleic and linoleic acids have been found in P. cineraria. Some of these extracts can be applied for creating a face, hand, anti-aging, and hair masks and lipsticks. Fatty acids are employed as emollients capable of softening and smoothing the skin and as emulsifying agents. Gallic acid and rutin are antioxidants that prevent rancidity and oxidation and can be used in anti-aging face creams with properties comparable to luteolin.
• Pods: yellow to reddish brown with cylindrical shape and 20-cm long by 0.8-cm thick. The main extracted molecules are fructose, alkaloids such as prosophylline, amino acids, saponin, 3-benzyl-2-hydroxy-urs-12-en-28-oic acid, and maslinic acid-3-glucoside (triterpenoids); flavonoids such as vitexin, puerarin, phloridzin, and daidzein; linoleic acid; 5,5′-oxybis-1,3-benzenediol and 5,3′,4′-trihydroxyflavanone 7-glycoside (polyphenols) (Karim and Azlan, 2012; Liu et al., 2012; Garg and Mittal, 2013; Afifi and Al-rub, 2018; Asati et al., 2022; Ram et al., 2022; Zhong et al., 2022). In particular, the amino acids isolated from both leaves and pods are Asp, Glu, Ser, Gly, His, Thr, Arg, Ala, Pro, Tyr, Val, Met, Cys, Ile, Leu, Phe, and Lys (Khatri et al., 2010). These molecules are also well-received by INCI. The listed amino acids are used in the formulation of skin and hair care. The addition to the formulations of flavonoids, such as those mentioned above, provides benefits against skin aging.
• Leaves (Malik and Kalidhar, 2007; Garg and Mittal, 2013; Mohammad et al., 2013; Pareek et al., 2015; Afifi and Al-rub, 2018; Islam et al., 2019; Kulshreshtha et al., 2019; Sharifi-Rad et al., 2019): gray green with an oblique shape. Besides the same amino acids detected in the pods (Khatri et al., 2010), phytoconstituents can be extracted from the leaves, including campesterol, cholesterol, sitosterol, stigmasterol, octacosanol, hentriacontane, methyl docosanoate, diisopropyl-10,11-dihydroxyicosane-1,20-dioate, tricosan-1-ol, and 7,24-tirucalladien-3-one, and quercetin derivatives (Akhtar et al., 2022). Leaves are already employed to treat mouth ulcers or to treat open sores on the skin (Afifi and Al-rub, 2018). The extracted compounds are good according to INCI and can be applied to body and face creams, emulsions, and lotions. Moreover, the presence of phytosterols and, fatty alcohols, such as tricosan-1-ol allows for better skin hydration, reducing the erythema index, and protecting the skin from stress phenomena. It could be able to improve the stability and smoothness of formulations, donating them consistency given the long carbon chain playing a role in the chemical–physical properties.
• Flowers (Khatri et al., 2010; Garg and Mittal, 2013; Pareek et al., 2015; Afifi and Al-rub, 2018): yellow, thin, and pedunculated around 10 cm long. From flowers, it is possible to isolate molecules such as patuletin, patulitrin, luteolin, rutin, sitosterol, spicigerine, prosogerin A and B. Some of these have been already described previously and used in cosmetics (refer to Table 2). Furthermore, flowers are a fundamental resource for bees in obtaining honey. This product can be used as an emollient, humectant, and soothing and prevents pathogenic infections.
• Bark (Garg and Mittal, 2013; Pareek et al., 2015; Afifi and Al-rub, 2018; Mohammad et al., 2018) and trunk can be exploited in extracting lignin and starch, already used in cosmetics. Other molecules obtainable from the purification of these components are hexacosan-25-on-1-ol, vitamin K1, n-octacosyl acetate, glucose, rhamnose, and sucrose (Islam et al., 2019). As previously mentioned, the advantage of fatty alcohols, in this case, hexacosan-25-on-1-ol, can change the consistency of the formulation. While molecules such as glucose, rhamnose, and sucrose are often used as humectants and soothing agents in formulations such as creams, scrubs, and shower gels.
Eventually, a resin tree or Mesquite Gum can be obtained from the plant and employed for encapsulation of active compounds, fragrances, and natural colors, acting as an emulsifier in oil-to-water processes (Afifi and Al-rub, 2018; Mudgil and Barak, 2020; Vadapalani Nallasivam and Gokhale, 2022).
Discussion
The Ghaf (i.e., P. cineraria), the national tree of the UAE, is known for its ability to withstand and thrive in challenging environmental conditions. It serves as a hopeful symbol for the important work being carried out to advance farming methods across the Emirates. For countries like UAE, where arid conditions are present, identification of such tree that is considered resident, resistant, and remedial becomes an opportunity for agroforestry. Investigative research targeting the commercialization of Ghaf tree products, including extracting, manufacturing, and marketing operations would be useful in achieving a triple bottom line of sustainability. Such research would support not only ecological biodiversity but also economic viability through Ghaf tree production in the UAE. Due to remedial benefits and local traditions, there is a great potential for commercialization of the Ghaf tree as the research found that despite the Western medicine adoption of the country in its healthcare system, herbal medicines, and remedies are also commonly used by the UAE nationals (AlBraik et al., 2008).
From a nutritional point of view, P. cineraria seeds are very important as they are considered a potential and cheap source of protein for industrial use, especially for numerous people in Africa and Asia who are suffering from protein and mineral deficiency due to malnutrition problems. By a grinding process of the mesocarp part of its pods, is obtained flour that contains 62% of proteins, 25% of dietary fiber, a large amount of free polyphenols and carotenoids, and low content of total carbohydrates and fat, as well as a source of calcium, potassium, magnesium, zinc, and iron (Afifi and Al-rub, 2018). Its pods are known to be rich sources of vitamin C, calcium, and iron, and to be effective in the prevention of protein–calorie malnutrition and iron–calcium deficiency in the blood (Asati et al., 2022). It is much higher in lysine than the other cereals and it is particularly appropriate for vegetarians who often lack this amino acid. Moreover, the flour is particularly suitable for patients with diabetes because the pods contain fructose which the body can metabolize without insulin and helps keep blood sugar constant over time. In fact, studies showed that it releases sugars into the blood much more slowly than wheat flour (Pasiecznik et al., 2007).
As the Ghaf can grow without irrigation and fertilization, it may create an economical advantage due to its low maintenance costs, and if the tree can be fully utilized, it could take its place in the UAE economy as an attractive agricultural investment tool. At the same time, the economic contribution of the tree may provide various benefits to the social sustainability of the country in terms of job creation and increasing quality of life, health, and well-being. For all these reasons, it is very important to create a market for the products to be obtained from the Ghaf tree. Provided that the nutritional values of this plant, as well as the potential curative effects of the extracts from its various components have been established, novel sustainable opportunities for the development of innovative products also in side fields with high economic impact, including cosmetic and luxury, are readily expected. To determine the actual potential of these products, first of all, intense scientific research is needed to challenge new isolation, production, and scale-up processes. Among the different challenges in which researchers and companies are trying to act promptly, P. cineraria is estimated to have a big impact on the eco-sustainability of products by reducing waste of resources and employing eco-friendly materials (natural origin or renewable biomass). In particular, the research effort should apply to all the components of cosmetics and luxury in general, spanning from formulation to packaging. The concept of eco-sustainability is closely related to green chemistry and more rational use of resources such as water and renewable and clean energy sources. Especially with the rise in Earth's temperature, the disproportionate use of resources in all productivity fields, including pharma, food, and luxury, must be stopped.
Conclusion
Sustainability is increasingly considered the new frontier of luxury. Starting from this assumption, the above considerations suggest that the cosmetic products obtained by P. cineraria could be able to perfectly combine these two concepts paving the way to a new era of eco-luxury.
Indeed, a critical issue relating to the widespread increase of luxury and cosmetics in the marketplace, which must be considered urgently, concerns microplastic replacement. This concrete problem is leading to consequences for the entire ecosystem damaging the flora and fauna of the planet. In fact, from recent studies, microparticles were detected in the respiratory and circulatory human systems (Jenner et al., 2022; Leslie et al., 2022). The use of raw materials from natural sources, such as P. cineraria, turns out to be a valid alternative to hit the targets. As mentioned, it is a plant able to grow in hostile environments by also providing nutrients for populations of Western Asia and the Indian Subcontinent. This plant can be a weighty competitor compared to eco-friendly components already used in different formulations, not only reaching the mentioned goals but also fighting the greenwashing concept by exploiting the 3G principle: “Give a Ghaf as a Gift” from nature.
Author contributions
MC and PG conceived the study. MG, FC, YA, and MC wrote the first draft. TAA, LS, PG, and DP reviewed and edited the manuscript. All authors contributed to the article and approved the submitted version.
Funding
This study was supported by the Italian funds of the PNRR, MUSA project: Multilayered Urban Sustainability Action.
Acknowledgments
The authors want to thank Goumbook, the social enterprise that promotes sustainable living and ecological practices in the United Arab Emirates and beyond. Thanks to Goumbook, the authors were introduced to the importance of Ghaf for the UAE.
Conflict of interest
Author TAA was employed by company Goumbook.
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Keywords: Prosopis cineraria, eco-sustainability, arid regions, agrofood, cosmetics, pharmaceutics, natural products
Citation: Giustra M, Cerri F, Anadol Y, Salvioni L, Antonelli Abella T, Prosperi D, Galli P and Colombo M (2022) Eco-luxury: Making sustainable drugs and cosmetics with Prosopis cineraria natural extracts. Front. Sustain. 3:1047218. doi: 10.3389/frsus.2022.1047218
Received: 23 September 2022; Accepted: 17 October 2022;
Published: 16 November 2022.
Edited by:
Muhammad Tayyab, Lahore University of Management Sciences, PakistanReviewed by:
Pankaj Sharma, Birla Institute of Technology and Science, IndiaCopyright © 2022 Giustra, Cerri, Anadol, Salvioni, Antonelli Abella, Prosperi, Galli and Colombo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Miriam Colombo, bWlyaWFtLmNvbG9tYm8mI3gwMDA0MDt1bmltaWIuaXQ=
†These authors share first authorship
‡These authors share last authorship