CASE REPORT article
Front. Surg.
Sec. Neurosurgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1587988
Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review
Provisionally accepted
- 1Tianjin Medical University General Hospital, Tianjin, China
- 2Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
- 3Nanping First Hospital affiliated to Fujian Medical University, Nanping,FuJian Province, China
- 4Xuanwu Hospital, Capital Medical University, Beijing, Beijing Municipality, China
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Epidural hematomas (EDH), typically requiring surgery, may be managed conservatively in select patients. We investigated atorvastatin (10 mg/d) combined with dexamethasone (2.25 mg/d) as conservative therapy in six EDH patients (GCS ≥ 13, volume < 30 mL) posttrauma. All patients recovered fully without surgery, and literatures support conservative care for stable EDH. Our findings suggest this combination therapy may promote hematoma absorption. In conclusion, atorvastatin/dexamethasone shows promise as a nonsurgical EDH option, warranting further investigation.
Keywords: Epidural hematoma, conservative treatment, atorvastatin, Dexamethasone, Meningeal lymphatic system
Received: 06 Mar 2025; Accepted: 15 Apr 2025.
Copyright: © 2025 Wu, Tian, Zhao, Chen, Xu, Huang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chenrui Wu, Tianjin Medical University General Hospital, Tianjin, China
Rongcai Jiang, Xuanwu Hospital, Capital Medical University, Beijing, 100053, Beijing Municipality, China
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