CASE REPORT article
Front. Surg.
Sec. Orthopedic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1544336
This article is part of the Research TopicInnovations in Knee Preservation and Arthroplasty: Advancing Techniques and Technologies for Enhanced Surgical OutcomesView all 4 articles
Case Report: Application of Tumor-Bearing Bone Inactivation and Bilateral Fibula Grafting in Joint-Sparing Surgery for Osteosarcoma Patient
Provisionally accepted
- Lanzhou University Second Hospital, Lanzhou, China
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On August 28th, 2023, a 13-year-old male was diagnosed with conventional osteosarcoma of the proximal left tibia after a needle biopsy. Subsequently, the patient received two cycles of neoadjuvant chemotherapy and four cycles of postoperative chemotherapy. On December 27, 2023, the tumor resection was performed while preserving the knee joint, which involved inactivation of the tumor-bearing bone, autologous bilateral fibula grafting, and fixation of the grafted bone to the host bone using plate and screws. Follow-up after surgery included X-rays and CT scans. On February 28, 2024, two months after the surgery, new bone formation was noted at the site from which bone was harvested from the right fibula, the left knee joint had satisfactory range of motion in flexion (130°) and extension (0°). Additionally, partial healing of both the grafted bone and the host bone was observed. In the follow-up on September 23rd, 2024, nine months post-operation, the right fibula had reformed. Furthermore, the transplanted and host bones of the left tibia had healed securely. It was confirmed that there was no recurrence or metastasis of the tumor during the last followup by ECT. This case highlights the feasibility and effectiveness of using inactivating tumor-bearing bone and autologous bilateral fibular grafting to repair large bone defects after joint-sparing surgery for malignant tumors near the joints.
Keywords: Osteosarcoma, Tumor-bearing bone inactivation, Autologous fibula grafting, Joint-sparing surgery, Bone defect reconstruction
Received: 12 Dec 2024; Accepted: 09 Apr 2025.
Copyright: © 2025 Wang, Xu, Mai and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kai Yang, Lanzhou University Second Hospital, Lanzhou, China
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