Long-Term Prognosis and Risk Factors in Tricuspid Valve Replacement Surgery: A Single-Center Study

Yingjie Ke ^1,2 Linbin Hua ¹ Shanwen Pang ¹ Qiuji Wang ¹ Lishan Zhong ¹ Zhenzhong Wang ¹ Kan Zhou ^1,3 Rong Zeng ^4* Huanlei Huang ^1,2,3*

• ¹ Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080, China, Guangzhou, China
• ² Guangdong Provincial People's Hospital's Nanhai Hospital, The Second People's Hospital of Nanhai District Foshan City, Foshan, 528200, Guangdong, China, Foshan, China
• ³ School of Medicine, South China University of Technology, Guangzhou, 510640, P. R. China, Guangzhou, China
• ⁴ Guangdong Provincial First Veterans Hospital, Guangzhou, 510260, P. R. China., Guangzhou, China

Background: Tricuspid valve replacement (TVR), although accounting for a minority of heart valve surgeries, poses significant challenges, including poor patients' condition, prosthetic complications, and increased perioperative mortality rates. Despite preferences for valvuloplasty, some cases necessitate replacement. The choice of tricuspid valve type remains controversial, and there is no consensus on surgical risk factors. Additionally, long-term follow-up reports on a large number of cases are lacking. In this study, we aimed to analyze the medical records of the largest number of patients who underwent TVR surgery.Methods: Patients who underwent TVR between 1999 and 2023 were divided into mechanical (MTVR) and bioprosthetic (BTVR) groups. Risk factors for overall mortality were analyzed.Results: In total, 626 patients were enrolled. The in-hospital and overall mortality rates were 12.1% and 42.8%, respectively.The in-hospital mortality rate (7.0% vs. 14.2%), incidence of acute renal insufficiency (4.3% vs. 12.2%), and hemodialysis rate (3.2% vs. 10.4%) were significantly higher in the BTVR group than in the MTVR group (P<0.01). The median follow-up was 11 years (range 0.1-24 years). The MTVR group had significantly higher rates of long-term survival, hemorrhagic events, heart failure events, and re-operation rates than the BTVR group (P<0.01). Multifactorial logistic regression analysis identified body weight, New York heart function classification, extracorporeal circulation time, and ventilator time as independent risk factors for in-hospital mortality. New York heart function classification during follow-up was identified as an independent risk factor for overall patient mortality.Conclusions: MTVR was superior to BTVR regarding short-and long-term outcomes. New York heart function classification was associated with short-and long-term mortality.