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SYSTEMATIC REVIEW article
Front. Surg.
Sec. Visceral Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1529279
Enhanced recovery after surgery(ERAS) or Fast track surgery(FTS) and the perioperative period of acute gastrointestinal perforation: A systematic review and Meta-analysis
Provisionally accepted- 1 Hebei Provincial Children's Hospital, Shijiazhuang, Hebei Province, China
- 2 Department of Emergency Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, China
- 3 Yi County Hospital of Traditional Chinese Medicine, Baoding, China
- 4 People's Hospital of Hengshui, Hengshui, China
Background: Reports of an association between Enhanced recovery after surgery(ERAS) or Fast track surgery(FTS) and the perioperative period of acute gastrointestinal perforation is inconsistent.Therefore, we systematically evaluate the safety and efficacy of ERAS or FTS in the perioperative of acute gastrointestinal perforation.Randomized controlled trial (RCT) or controlled clinical trial (CCT) on the application of ERAS/FTS in perioperative management of acute gastrointestinal perforation was conducted by Pubmed, MEDLINE, web of Science, Ovid, Elsevier Science direct, Cochrane Library, EMBASE, CNKI, CBM, Wanfang and whip, the methodology quality and data extraction were evaluated by two researchers, and meta-analysis was performed by Stata 11 software.Results 20 RCT and 7 CCT literatures were included in the study, totaling 1864 patients, 917 in the ERAS/FTS Group and 947 in the control group. The results of meta-analysis showed that the stress response CRP and complication rate of ERAS/FTS group were significantly lower than those of traditional treatment group, the time of first out-of-bed activity, the time of postoperative first exhaust and eating were advanced, and the cost and the length of hospital stay were decreased (P < 0.05),Egger's test showed no publication bias (P > 0.1).However, only 2 and 3 studies mentioned operative time and pain management, respectively, the meta-analysis could not be performed.The application of ERAS/FTS in perioperative management of acute gastrointestinal perforation is safe and effective.
Keywords: Perioperative Period, Enhanced recovery after surgery, Fast track surgery, Acute gastrointestinal perforation, Meta-analysis, Systematic review
Received: 19 Nov 2024; Accepted: 06 Mar 2025.
Copyright: © 2025 Qiu, Wang, Qu, Li, Xu and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanwei Fang, Department of Emergency Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, China
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