Random Forests Algorithm Using Basic Medical Data for Predicting the Presence of Colonic Polyps

Mihaela-Flavia Avram ^1* Nicolae Lupa ² Dimitrios Koukoulas ³ Daniela Cornelia Lazar ¹ Mihaela Ioana Maris ¹ Marius Sorin Murariu ¹ Sorin Olariu ¹

• ¹ Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
• ² Politehnica University of Timișoara, Timișoara, Romania
• ³ Department of Gastroenterology, Municipal Hospital “Dr. Teodor Andrei” Lugoj, Romania, Lugoj, Romania

Background: Colorectal cancer is considered to be triggered by the malignant transformation of colorectal polyps. Early diagnosis and excision of colorectal polyps has been found to lower the mortality and morbidity associated with colorectal cancer.The aim of this study is to offer a predictive model for the presence of colorectal polyps based on Random Forests machine learning algorithm, using basic patient information and common laboratory test results.Materials and methods: 164 patients were included in the study. The following data was collected: sex, residence, age, diabetes mellitus, body mass index, fasting blood glucose levels, hemoglobin, platelets, total, LDL and HLD cholesterol, triglycerides, serum glutamic-oxaloacetic transaminase, chronic gastritis, presence of colonic polyps at colonoscopy. 80% of patients were included in the training set for creating a Random forests algorithm, 20% were in the test set. External validation was performed on data from 42 patients. The performance of the Random Forests was compared with the performance of a generalized linear model (GLM) and support vector machine (SVM) built and tested on the same datasets.The Random Forest prediction model gave an AUC of 0.820 on the test set. The top five variables in order of importance were: body mass index, platelets, hemoglobin, triglycerides, glutamic-oxaloacetic transaminase. For external validation, the AUC was 0.79. GLM performance in internal validation was an AUC of 0.788, while for external validation AUC-0.65. For SVN, the AUC -0.785 for internal validation and 0.685 for the external validation dataset.A random forest prediction model was developed using patient's demographic data, medical history and common blood tests results. This algorithm can foresee, with good predictive power, the presence of colonic polyps.