ORIGINAL RESEARCH article
Front. Surg.
Sec. Neurosurgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1503977
Clinical efficacy, safety, and prognostic assessment of neurointerventional surgery versus craniotomy in patients with cerebral aneurysms
Provisionally accepted
- Ruian People's Hospital, Wenzhou, Zhejiang Province, China
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To analyze the differences in clinical efficacy and safety between neurointerventional surgery and craniotomy in the treatment of patients with cerebral aneurysms and investigate their impact on patient prognosis. In this retrospective analysis, 98 patients who were diagnosed with cerebral aneurysms and underwent surgical treatment in our hospital from September 2020 to October 2023 were selected as the subjects of the study. They were categorized into two groups based on the difference in surgical procedures: the intervention group (n=50, IG) and the craniotomy group (n=48, CG). The IG showed shorter length of stay, lower intraoperative bleeding, and longer operative time than the CG (P = 0.036, P = 0.015, P = 0.005). At 3 days postoperatively, the IG exhibited lower middle cerebral artery blood flow velocity and higher regional cerebral oxygen saturation levels than the CG (P = 0.023, P = 0.018). At 3 days postoperatively, the levels of endothelin-1 and S100 calcium-binding protein B were lower in the IG than in the CG (P = 0.015, P = 0.026). At 3 days postoperatively, the Mini-Mental State Examination scores were higher in the IG than the CG (P = 0.006). At 6 months postoperatively, the proportion of Hunt-Hess grade I in the IG was 32.00% (16/50), which was higher than that in the CG (14.58%, 7/48) (χ² = 4.136, P = 0.042). At 6 months postoperatively, the incidence of complications in the IG was lower than in the CG (χ² = 11.707, P = 0.001). At 6 months postoperatively, there was no statistically significant difference in prognosis between the IG and CG (χ² = 0.653, P = 0.451). At 6 months postoperatively, the IG demonstrated higher scores in activities of daily living and communication abilities (P = 0.016, P = 0.006), and showed lower Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores compared to the CG (P = 0.008, P = 0.018). In contrast to traditional craniotomy clipping, neurointerventional surgery typically requires a longer duration for treating cerebral aneurysms, but it contributes to mitigating patient trauma, reducing the incidence of complications.
Keywords: Neurointervention, cerebral aneurysms, Craniotomy clipping, clinical efficacy, cerebral vasospasm
Received: 30 Sep 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Cai, Yang, Zhuang, He, Yu and Lou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiao-Hui Lou, Ruian People's Hospital, Wenzhou, Zhejiang Province, China
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