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ORIGINAL RESEARCH article
Front. Surg.
Sec. Surgical Oncology
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1443605
Development and validation of nomograms to forecast overall survival and cancer-specific survival in Asian patients diagnosed withepithelial ovarian cancer
Provisionally accepted- 1 Department of Gynecologic Oncology, Zhongnan hospital of Wuhan university, Wuhan, China
- 2 Department of Gynecology, Xianning Central Hospital, Xianning, China
- 3 Department of Obstetrics, First Hospital of Lanzhou University, Lanzhou, China
Objective: Asian females with ovarian cancer have different clinicopathological characteristicscompared with other races. However, an effective prognostic prediction tool is lacking. The goal of our study was to develop and evaluate nomograms for estimating overall survival and cancer-specific survival in Asian patients with ovarian cancer.Methods: We extracted data from 2010 to 2018 in the Surveillance, Epidemiology, and End Results database, focusing on Asian/Pacific Islander females that had been diagnosed with epithelial ovarian cancer. To find prognostic factors, least absolute shrinkage and selection operator Cox regression and multivariate Cox regression analyses were used. Based on the outcomes, nomograms were then constructed. Numerous techniques, such as the C-index, calibration plots, decision curve analysis, and risk subgroup stratification, were used to assess the performance of the nomograms.Results: Nomograms were created to evaluate overall survival and cancer-specific survival rates over three and five years. The C-indices for overall survival and cancer-specific survival in the training cohort were 0.768 and 0.778, respectively. The C-indices for overall survival and cancer-specific survival in the validation cohort were 0.804 and 0.812, respectively. The calibration plots showed that the nomogram forecasts and actual survival results agreed. Additionally, the decision curve analysis curves indicated that the nomogram outperformed the American Joint Commission on Cancer staging system in terms of predictive accuracy.Conclusion: Nomograms and a risk classification system were created to forecast the overall survival and cancer-specific survival of Asian females with ovarian cancer. The nomograms and risk stratification system have the potential to provide valuable assistance in making future clinicaldecisions.
Keywords: epithelial ovarian cancer, Asian females, nomogram, SEER, overall survival, 12 cancer-specific survival
Received: 24 Aug 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 He, Cheng, Zhao, Wan, Yao and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongbing Cai, Department of Gynecologic Oncology, Zhongnan hospital of Wuhan university, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.