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ORIGINAL RESEARCH article

Front. Surg.
Sec. Obstetrics and Gynecological Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1406425

Meta-Analysis of Risk Factors for Postoperative Lower Extremity Deep Vein Thrombosis in Patients with Gynecologic Malignancies

Provisionally accepted
Danzhu Gong Danzhu Gong Qi Wang Qi Wang *
  • Linhai Hospital of Traditional Chinese Medicine, Linhai, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    This study aims to elucidate the risk factors associated with postoperative lower extremity deep vein thrombosis (DVT) in patients afflicted with gynecologic malignancies. A comprehensive search was conducted across CNKI, CQVIP, Wanfang, and PubMed databases for literature published from January 1, 2024, concerning the risk factors for postoperative DVT in patients with gynecologic cancers. Two researchers independently and objectively screened, extracted, and evaluated the pertinent data. Subsequently, the extracted data were subjected to meta-analysis using STATA software. A total of twelve studies fulfilling the inclusion criteria were analyzed, encompassing 2,553 cases. The meta-analysis revealed that significant risk factors for postoperative lower extremity DVT in patients with gynecologic malignancies include age (Odds Ratio [OR]=1.35, 95% Confidence Interval [CI] [1.19, 1.54], P<0.001), Body Mass Index (BMI) (OR=1.67, 95% CI [1.05, 2.66], P<0.001), plasma D-dimer levels (OR=3.39, 95% CI [1.24, 9.24], P<0.001), duration of surgery (OR=2.24, 95% CI [1.24, 4.01], P<0.001), and duration of postoperative bed rest (OR=2.14, 95% CI [1.56, 2.94], P<0.001). The study identifies multiple risk factors influencing the incidence of postoperative lower extremity DVT in patients with gynecologic malignancies. Notably, age, BMI, plasma D-dimer levels, surgical duration, and postoperative bed rest emerge as significant predictors. These findings underscore the necessity for targeted prophylaxis and therapeutic interventions in the clinical management of such patients.

    Keywords: Postoperative Gynecologic Malignancy, Lower extremity deep vein thrombosis, Risk factors, Meta-analysis, prophylaxis, Interventions

    Received: 25 Mar 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Gong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qi Wang, Linhai Hospital of Traditional Chinese Medicine, Linhai, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.