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ORIGINAL RESEARCH article

Front. Surg.
Sec. Otorhinolaryngology - Head and Neck Surgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1516981

Relationship Between Serum ECP and TIgE Levels and the Risk of Postoperative Recurrence in Patients with Chronic Rhinosinusitis with Nasal Polyps

Provisionally accepted
Qing Zhang Qing Zhang 1*Hui Li Hui Li 2Di Xie Di Xie 2SiJian Fan SiJian Fan 2
  • 1 Yongkang Maternal and Child Health Hospital, Zhejiang Province, China, Yongkang, China
  • 2 Pei County People's Hospital, Jiangsu Province, China, Xuzhou, China

The final, formatted version of the article will be published soon.

    Objective: This study was undertaken to assess the association between the likelihood of surgical recurrence and serum ECP and TIgE levels in chronic rhinosinusitis with nasal polyps (CRSwNP). Methodology: Clinical information was gathered retrospectively from 166 cases of surgically treated CRSwNP as well as 60 cases of chronic rhinosinusitis without nasal polyps (CRSsNP). A comparative analysis on serum levels of total immunoglobulin E (TIgE) and eosinophil cationic protein (ECP) was carried out between the two groups. The CRSwNP patients were assigned into recurrence and non-recurrence groups based on the absence/presence of disease recurrence after a two-year follow-up. An analysis was conducted on the correlation between the patients' clinical data and their serum ECP and TIgE levels. Receiver operating characteristic (ROC) curves were utilized to assess the clinical utility of these two biomarkers. Results: The CRSwNP participants had higher serum levels of ECP and TIgE (4.28±0.81>3.58±0.77 ng/L, P<0.001; 52.99±8.62>15.65±3.25 KU/L, P<0.001) compared to CRSsNP participants. Univariate analysis indicated that neutrophil ratio, lymphocyte ratio, Lund-Kennedy score, Lund-Mackay score, SNOT-22 score, olfactory function score, and postoperative recurrence were significantly correlated with serum ECP and TIgE levels. Higher serum levels of TIgE and ECP (4.89±0.79<4.11±0.72, P<0.001; 58.74±8.27<51.40±8.04, P<0.001) were detected in the recurrence groups versus the non-recurrence group. Multivariate analysis showed that serum ECP and TIgE were independent risk factors for recurrence of CRSwNP. Serum ECP and TIgE levels were found to be predictive of postoperative recurrence risk in CRSwNP patients (AUC: 0.77, 0.74, 0.84; P<0.05) according to ROC curve analysis. Significant differences were not observed in any general clinical data. Conclusion: The findings suggest that elevated serum ECP and TIgE levels in patients with CRSwNP can be as good predictors for the risk of recurrence after endoscopic sinus surgery.

    Keywords: chronic rhinosinusitis with nasal polyps, Eosinophil Cationic Protein, Total immunoglobulin E, Endoscopic sinus surgery, recurrence risk

    Received: 25 Oct 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Zhang, Li, Xie and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qing Zhang, Yongkang Maternal and Child Health Hospital, Zhejiang Province, China, Yongkang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.