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CLINICAL TRIAL article

Front. Surg.
Sec. Orthopedic Surgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1515610

Hemostatic effect of oxidized regenerated cellulose versus topical tranexamic acid in total knee arthroplasty-a prospective randomized controlled trial

Provisionally accepted
Bowei Li Bowei Li Wenjie Pan Wenjie Pan *Jianbing Ma Jianbing Ma *Yuanchi Huang Yuanchi Huang *
  • Xi'an Honghui Hospital, Xi'an, China

The final, formatted version of the article will be published soon.

    This study compared the hemostatic effects and complications of oxidized regenerated cellulose (ORC) and topical TXA in total knee arthroplasty (TKA), thus providing a reference for the use of ORC as an alternative hemostatic agent to TXA in TKA.A total of 105 patients were included in this study and randomized into blank control, ORC, and TXA groups. The primary outcomes were total blood loss, hemoglobin drop (Hb drop), transfusion rates, and incidence of thrombosis. The secondary outcomes included operation time, tourniquet duration, coagulation parameters, inflammation markers, and complication rates.Total blood loss was 1002.47±308.58 mL and 964.68±273.00 mL in the ORC and TXA groups, respectively, both significantly lower than that in the blank control group (1168.94±405.04 mL) (P1=0.043 and P2=0.014, respectively). Hb Drop was statistically insignificantly different between the ORC (36.03±12.17 g/L) and TXA (34.32±10.19 g/L) groups (P=0.555). There was no statistically significant difference in transfusion rate, operation time, tourniquet duration, coagulation parameters, inflammation markers, and complication rates among the three groups.In conclusion, our prospective randomized controlled trial (RCT) highlights that, oxidized regenerated cellulose (ORC) can reduce postoperative invisible blood loss in total knee arthroplasty and achieve a hemostatic effect similar to topical tranexamic acid (TXA). This provides a safe and effective hemostatic option for patients with severe underlying diseases or contraindications to tranexamic acid.Trial registration: This trial was registered on the Chinese Clinical Trial Registry (ChiCTR2200066633), and performed between December 15, 2022, and March 15, 2023.

    Keywords: Tranexamic Acid, Oxidized regenerated cellulose, Total knee arthroplasty, Total blood loss, Hemoglobin drop

    Received: 23 Oct 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Li, Pan, Ma and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wenjie Pan, Xi'an Honghui Hospital, Xi'an, China
    Jianbing Ma, Xi'an Honghui Hospital, Xi'an, China
    Yuanchi Huang, Xi'an Honghui Hospital, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.