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ORIGINAL RESEARCH article

Front. Surg.
Sec. Genitourinary Surgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1489397

Efficacy and cost-effectiveness analysis of flexible ureteroscopic lithotripsy with TFDS in the treatment of urolithiasis

Provisionally accepted
Xiang Gao Xiang Gao 1Peng Han Peng Han 2Yiping Zong Yiping Zong 3Zijie Wang Zijie Wang 2Wei Zhang Wei Zhang 2Pei Lu Pei Lu 2*
  • 1 Department of Pediatrics, Second Affiliated Hospital of Nanjing Medical University, Nangjing, China
  • 2 First Affiliated Hospital, Nanjing Medical University, Nanjing, China
  • 3 Yixing People's Hospital, Yixing, Jiangsu, China

The final, formatted version of the article will be published soon.

    Background: At present, there is no effective drug to remove residual stones. Total flavonoids of desmodium styracifolium (TFDS) is an innovative traditional Chinese medicine listed in 2022, which can be used to treat ureteral calculi. This study was to explore the effectiveness and economic value of TFDS in the treatment of residual stones after flexible ureteroscopic lithotripsy (FURL). Methods: A total of 161 patients who underwent unilateral ureteroscopic lithotripsy for urinary calculi by the same surgeon in our center from May 2022 to February 2024 were retrospectively included. According to the use of stone-removal drugs after operation, patients were divided into TFDS group and Control group. The residual stones showed by X-ray plain film when the double J tube was removed were compared between the two groups, and the economic benefits of TFDS were analyzed by cost-benefit analysis. Results: The data of 161 patients were collected, including 80 cases in TFDS group and 81 cases in Control group. The SFR rates at the endpoint of follow-up in TFDS group and Control group were 98.75% and 88.88%, respectively. In the subgroup analysis of post-operative residual stones, the stone clearance rate of TFDS was higher (47.62% vs. 18.18%). No obvious adverse events were reported in two groups. The cost/benefit ratio of TFDS was lower (20.43 vs. 32.57). Cost of TFDS was increased by ¥12.97 for each additional unit of total effective rate. Conclusion: The combination of dusting FURL and TFDS can effectively remove the urolithiasis when compared to only FURL, which showed highly economic benefits.

    Keywords: total flavonoids of Desmodium styracifolium, Furl, Cost-effective analysis, Urolithiasis, Efficacy & safety

    Received: 01 Sep 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Gao, Han, Zong, Wang, Zhang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Pei Lu, First Affiliated Hospital, Nanjing Medical University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.