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SYSTEMATIC REVIEW article

Front. Surg.
Sec. Obstetrics and Gynecological Surgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1481625
This article is part of the Research Topic 10th Anniversary of Frontiers in Surgery: Celebrating Progress and Envisioning the Future of Multidisciplinary Surgery View all articles

Role of lymphadenectomy in advanced-stage ovarian cancer: a Meta-analysis

Provisionally accepted
Carlo Ronsini Carlo Ronsini 1*Francesca Pasanisi Francesca Pasanisi 1Giada Andreoli Giada Andreoli 1Pasquale De Franciscis Pasquale De Franciscis 1Luigi Cobellis Luigi Cobellis 1Giuseppe Vizzielli Giuseppe Vizzielli 2Stefano Restaino Stefano Restaino 2Paola Romeo Paola Romeo 3Vittorio Palmara Vittorio Palmara 3Stefano Cianci Stefano Cianci 3*
  • 1 Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy
  • 2 Udine Obstetrics and Gynecology Clinic, Friuli Centrale University Health Authority, Udine, Italy
  • 3 Unit of Pathology, Department of Human Pathology in Adulthood and Childhood Gaetano Barresi, University of Messina, Messina, Sicily, Italy

The final, formatted version of the article will be published soon.

    Epithelial Ovarian Cancer is one of the most lethal cancers among gynecologic malignancies. The disease metastasizes mainly through the peritoneal spread in the abdomen and through the lymphatic system. Lymph node involvement is present in 48% up to 75% of cases of advanced-stage ovarian cancer (ASOC). In this context, the aim of our study is to analyze the current literature on the topic and to investigate survival outcomes in patients affected by advanced-stage ovarian cancer undergoing lymphadenectomy. Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched the Pubmed and Scopus databases in March 2024 since the first publication. We made no limitations on the country. We included the studies containing disease-free survival (DFS) and Overall Survival (OS) data. Only comparative studies with a direct comparison between Lymphadenectomy and its avoidance were included for meta-analysis. 18 studies fulfilled the inclusion criteria.The overall OS, DFS, and RR were comparable in the studies. 27983 patients were enrolled in the meta-analysis.Patients were analyzed concerning OS and DFS. Meta-analysis highlighted statistically significant higher OS than the lymphadenectomy group (RR 1.28 [95% CI 1.14-1.44] p < .00001), and no statistically different DFS RR 1.23 [95% CI 0.82-1.92] p=0.25). Our analysis showed a protective role of lymphadenectomy in advanced ovarian cancer, with a reduction in death risk.

    Keywords: Lymphadenectomy, ovarian cancer, Advanced Stage, overall survival, Disease free survival

    Received: 16 Aug 2024; Accepted: 01 Oct 2024.

    Copyright: © 2024 Ronsini, Pasanisi, Andreoli, De Franciscis, Cobellis, Vizzielli, Restaino, Romeo, Palmara and Cianci. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Carlo Ronsini, Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy
    Stefano Cianci, Unit of Pathology, Department of Human Pathology in Adulthood and Childhood Gaetano Barresi, University of Messina, Messina, 98122, Sicily, Italy

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