Skip to main content

ORIGINAL RESEARCH article

Front. Surg.
Sec. Neurosurgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1466924

Preoperative Anemia is Associated with Prolonged Hospital Stay and Increased Facility Discharges After Glioblastoma Resection

Provisionally accepted
Ahmad K. AlMekkawi Ahmad K. AlMekkawi 1*Ammar Adenwalla Ammar Adenwalla 2James P Caruso James P Caruso 2William H Hicks William H Hicks 2Benjamin Rail Benjamin Rail 2Carlos A Bagley Carlos A Bagley 1Jonathan D Breshears Jonathan D Breshears 1Tarek El Ahmadieh Tarek El Ahmadieh 3Samuel A Goldlust Samuel A Goldlust 4Tomas Garzon-Muvdi Tomas Garzon-Muvdi 5
  • 1 Saint Luke's Hospital, Kansas City, United States
  • 2 University of Texas Southwestern Medical Center, Dallas, Texas, United States
  • 3 Division of Neurosurgery, Loma Linda University Medical Center, Loma Linda, California, United States
  • 4 Saint Luke’s Cancer Institute, Saint Luke's Hospital, Kansas City, Kansas, United States
  • 5 Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia, United States

The final, formatted version of the article will be published soon.

    Background: Despite numerous operative and non-operative treatment modalities, patients with glioblastoma (GBM) have a dismal prognosis. Identifying predictors of survival and recurrence is an essential strategy for guiding treatment decisions, and existing literature demonstrates associations between hematologic data and clinical outcomes in cancer patients. As such, we provide a novel analysis that examines associations between preoperative hematologic data and postoperative outcomes following GBM resection.Methods: We performed a retrospective analysis of patients who underwent GBM resection from January 2016 to December 2020. Standard demographic and clinical variables were collected, including pre-operative complete blood count (CBC) , and inferential analyses were performed to analyze associations between CBC parameters and postoperative outcomes .Results: One hundred and eighty nine (189) patients met inclusion criteria, with a mean age of 60.7 years. On multivariate regression analysis, controlling for age, gender, and performance status, we observed trends suggesting anemic patients may have longer lengths of stay (t statistic = 3.23, p=0.0015) and higher rates of discharge to inpatient facilities (OR 3.01 [1.09 -8.13], p=0.029), though these associations did not reach statistical significance after correction for multiple comparisons (Bonferroni-corrected significance threshold p<0.01).Preoperative anemia may be a useful pre-operative predictor of postsurgical GBM outcomes. Further study is required to determine whether pre-operative hemoglobin optimization can improve postoperative clinical outcomes, and whether other hematologic and inflammatory markers are predictive of postoperative recovery and functional status.

    Keywords: Absolute lymphocyte count, Anemia, Glioblastoma, Neutrophil-lymphocyte ratio, postoperative outcomes Anemia, Glioblastoma, Resection

    Received: 18 Jul 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 AlMekkawi, Adenwalla, Caruso, Hicks, Rail, Bagley, Breshears, El Ahmadieh, Goldlust and Garzon-Muvdi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ahmad K. AlMekkawi, Saint Luke's Hospital, Kansas City, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.