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SYSTEMATIC REVIEW article

Front. Surg.
Sec. Colorectal and Proctological Surgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1450434
This article is part of the Research Topic Advances in Proctology and Colorectal Surgery Volume II View all 8 articles

Enhancing Recovery and Reducing Inflammation: The Impact of Enhanced Recovery After Surgery Recommendations on Inflammatory Markers in Laparoscopic Surgery – a Scoping review

Provisionally accepted
Carlos Darcy Alves Bersot Carlos Darcy Alves Bersot 1*Lucas Ferreira Gomes Pereira Lucas Ferreira Gomes Pereira 2Victor Gabriel Vieira Goncho Victor Gabriel Vieira Goncho 1Jose Eduardo Pereira Jose Eduardo Pereira 1Luiz Fernando Reis Falcao Luiz Fernando Reis Falcao 1
  • 1 Federal University of São Paulo, São Paulo, Brazil
  • 2 University of São Paulo, São Paulo, Rio Grande do Sul, Brazil

The final, formatted version of the article will be published soon.

    Introduction: The relationship between the Enhanced Recovery After Surgery (ERAS) guidelines and inflammatory markers in laparoscopic surgery has garnered increasing attention. These recommendations are designed to minimize surgical stress and potentially improve recovery outcomes by modifying perioperative care. Objective: This scoping review aims to evaluate the impact of ERAS recommendations on inflammatory markers in patients undergoing laparoscopic surgeries, identifying current research gaps and consolidating findings from existing studies. Methods: Guided by the Cochrane Handbook for Systematic Reviews and adhering to the PRISMA-ScR guidelines, this review analyzed studies from databases like PubMed, Scopus, and Cochrane Library. We included both randomized controlled trials and observational studies that assessed inflammatory markers such as C-reactive protein (CRP), white blood cells (WBC), and Interleukin-6 (IL-6) in laparoscopic surgery patients managed with ERAS recommendations. Results: Out of 64 initial studies, 7 met the inclusion criteria, involving a total of 2,047 patients. Most of the studies focused on laparoscopic colorectal surgeries. Commonly assessed markers were CRP and WBC. The findings consistently showed that ERAS guideline could mitigate the inflammatory response, evidenced by reduced levels of CRP and IL-6, which correlated with fewer postoperative complications and expedited recovery. Conclusion: ERAS recommendations appear to beneficially modulate inflammatory responses in laparoscopicsurgery, which suggests a potential for enhanced recovery outcomes. However, the evidence is currently limited by the small number of studies and inherent methodological biases. Further robust RCTs are required to strengthen the evidence base and refine these protocols for broader clinical application.

    Keywords: Enhanced recovery after surgery, Inflammation, Laparoscopy, Anesthesia, Surgery

    Received: 17 Jun 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Alves Bersot, Ferreira Gomes Pereira, Goncho, Pereira and Falcao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Carlos Darcy Alves Bersot, Federal University of São Paulo, São Paulo, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.