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ORIGINAL RESEARCH article

Front. Surg.
Sec. Neurosurgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1432029

An In vivo Evaluation of the Safety and Efficacy of Using Decellularized Bovine Parietal Peritoneum Membranes as Dural Substitutes

Provisionally accepted
Aidos Doskaliyev Aidos Doskaliyev 1*Vyacheslav Ogay Vyacheslav Ogay 2Islambek Mussabekov Islambek Mussabekov 1Muratbek Satov Muratbek Satov 1Berik Zhetpisbayev Berik Zhetpisbayev 1Khalit Mustafin Khalit Mustafin 1Xeniya Bobrova Xeniya Bobrova 1Raushan Auezova Raushan Auezova 1Serik Akshulakov Serik Akshulakov 1
  • 1 National Center for Neurosurgery, Nur-sultan, Kazakhstan
  • 2 National Center for Biotechnology, Astana, Kazakhstan

The final, formatted version of the article will be published soon.

    Purpose: The reconstruction of dura matter is a challenging problem for neurosurgeons. A number of materials for dural reconstruction have recently been developed, but some of them have poor biocompatibility, poor mechanical properties, and adverse effects. Bovine parietal peritoneum is a promising natural material for regenerative medicine and reconstructive surgery. In this study, we conducted an in vivo evaluation of the safety and efficacy of using decellularized bovine peritoneum membranes (BPMs) as natural dural substitutes in a rabbit model.Methods: The dural defects in mature New Zealand rabbits were studied. A BPM was sutured on the dural defect area of each animal. Autologous periosteum and collagen membranes (Lyoplant®) were used to facilitate a comparison with the BPMs. ELISA, histomorphological analysis, and hematological analysis were carried out to examine the safety and efficacy of using BPMs as dural substitutes.Results: Our results showed that the BPMs demonstrated a deterioration rate that is suitable for gathering newly formed meningothelial tissue. The thickness and density of BPM fibers prevents resorption in the first few days after use as a plastic material, and the regeneration of the dura mater does not occur at an accelerated pace, meaning that the gradual formation of fibrous tissue prevents adhesion to the brain surface. It was observed that the BPM can integrate with the adjacent tissue to repair dural defects. Moreover, the transplantation of BPMs did not cause significant adverse effects or immunological responses, indicating the safety and good biocompatibility of the BPM.Conclusion: Thus, our in vivo study in a rabbit model showed that decellularized BPMs may represent a biocompatible natural material that can be used in cases requiring dura matter repair without significant adverse effects.

    Keywords: bovine parietal peritoneum, Dural substitute, Duraplasty, Dura matter, Regeneration

    Received: 15 May 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Doskaliyev, Ogay, Mussabekov, Satov, Zhetpisbayev, Mustafin, Bobrova, Auezova and Akshulakov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Aidos Doskaliyev, National Center for Neurosurgery, Nur-sultan, Kazakhstan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.