Skip to main content

SYSTEMATIC REVIEW article

Front. Surg.
Sec. Neurosurgery
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1430567
This article is part of the Research Topic Training and Education in Neurosurgery: Strategies and Challenges for the Next Ten Years Volume II View all 6 articles

Neuronavigation in Glioma Resection: Current Applications, Challenges, and Clinical Outcomes

Provisionally accepted
Albert Joseph Sulangi Albert Joseph Sulangi 1*Adam Husain Adam Husain 2Haoyi Lei Haoyi Lei 3Jessica Okun Jessica Okun 4
  • 1 Nova Southeastern University, Fort Lauderdale, United States
  • 2 University of Texas Medical Branch at Galveston, Galveston, Texas, United States
  • 3 Elson S. Floyd College of Medicine, Washington State University Spokane, Spokane, Washington, United States
  • 4 Steward Medical Group, Fort Lauderdale, Florida, United States

The final, formatted version of the article will be published soon.

    Background: Glioma resection aims for maximal tumor removal while preserving neurological function. Neuronavigation systems (NS), with intraoperative imaging, have revolutionized this process through precise tumor localization and detailed anatomical navigation.Objective: To assess the efficacy and breadth of neuronavigation and intraoperative imaging in glioma resections, identify operational challenges, and provide educational insights to medical students and non-neurosurgeons regarding their practical applications.Methods: This systematic review analyzed studies from 2012 to 2023 on glioma patients undergoing surgical resection with neuronavigation, sourced from MEDLINE (PubMed), Embase, and Web of Science. A database-specific search strategy was employed, with independent reviewers screening for eligibility using Rayyan and extracting data using the Joanna Briggs Institute (JBI) tool.The integration of neuronavigation systems with intraoperative imaging modalities such as iMRI, iUS, and 5-ALA significantly enhances gross total resection (GTR) rates and extent of resection (EOR). While advanced technology improves surgical outcomes, it does not universally reduce operative times, and its impact on long-term survival varies. Combinations like NS + iMRI and NS + 5-ALA + iMRI achieve higher GTR rates compared to NS alone, indicating that advanced imaging adjuncts enhance tumor resection accuracy and success. The results underscore the multifaceted nature of successful surgical outcomes. Conclusions: Integrating intraoperative imaging with neuronavigation improves glioma resection. Ongoing research is vital to refine technology, enhance accuracy, reduce costs, and improve training, considering various factors impacting patient survival.

    Keywords: neuronavigation1, glioma resection2, High-grade glioma3, low-grade glioma4, intraoperative imaging5, surgical outcomes6, extent of resection7, gross total removal of tumor (GTR)8

    Received: 10 May 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Sulangi, Husain, Lei and Okun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Albert Joseph Sulangi, Nova Southeastern University, Fort Lauderdale, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.