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CASE REPORT article

Front. Surg.
Sec. Surgical Oncology
Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1430344

Fumarate hydratase-deficient renal cell carcinoma complicated with liver metastasis: Case report

Provisionally accepted
Hanmin Chen Hanmin Chen *Qingming Zeng Qingming Zeng Folin Liu Folin Liu ， X. Zou ， X. Zou
  • First Affiliated Hospital of Gannan Medical University, Ganzhou, China

The final, formatted version of the article will be published soon.

    Background: Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare subtype of kidney tumor. Most of them are solitary lesions, making preoperative diagnosis difficult, aggressive, and with poor prognosis. They may metastasize even at an early stage, however, there is currently no optimal diagnostic and therapeutic approach for metastatic FH-RCC.We report the case of a 34-year-old male patient with renal tumor and liver metastasis, who underwent open tumor resection of the right kidney combined with resection of liver metastases. Postoperative pathology was confirmed, followed by targeted therapy.Postoperative pathological results confirmed FH-RCC, targeted therapy was performed after surgery. No tumor recurrence was observed during the follow-up of almost 16 months.FH-RCC patients with liver metastasis can achieve a good prognosis through early resection of primary tumor and metastatic lesions combined with targeted therapy.

    Keywords: FH-RCC, liver metastasis, Surgery, targeted therapy, Good prognosis

    Received: 09 May 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Chen, Zeng, Liu and Zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hanmin Chen, First Affiliated Hospital of Gannan Medical University, Ganzhou, China

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